Advanced Organic Synthesis

Dmitry V. Liskin , PhD, is a lecturer at Christopher Newport University, Newport News, Virginia. He graduated with a degree in ACS biochemistry from Mississippi College, Clinton, Mississippi. As an undergraduate, he worked on the synthesis and characterization of pseudoacids under the mentorship of Dr. Edward Valente. He moved to Seattle, Washington, for his doctorate studies in organic chemistry at the University of Washington. He joined a research group of Dr. Forrest Michael and developed alkene difunctionalizations as novel routes to substituted nitrogen heterocycles, mainly focusing on the use of hypervalent iodine oxidants. Penny Chaloner , PhD, completed her undergraduate and graduate studies in Cambridge and had postdoctoral fellowships in Oxford, followed by a period in the United States as an assistant professor at Rutgers University and teaching at Harvard Summer School. She returned from the United States to a permanent position in Sussex, from which she recently retired. She first taught organic sophomore chemistry at Harvard in 1981 and has taught some version of this either once or twice a year ever since. Some of that was in North America, much in the United Kingdom, at Sussex, where for many years she taught the American organic chemistry sequence to visiting students, and to a large group of international premeds. Penny Chaloner has experience teaching this sequence in groups sized from two to almost a thousand.

Diastereoselective Reduction of Estrone. Synthesis of 2,2-Dimethyl-4-pentene-1-amine. Protection of 2,2-Dimethyl-4-pentene-1-amine. Optimization of the Reaction Conditions for the Aminofluorination of N-(2,2-Dimethylpent-4-enyl)-2-toluenesulfonamide. Asymmetric Robinson Annulation. Formation of N- Benzylcinchonidinium Chloride from Cinchonidine. Chiral Resolution of BINOL (1,1'-bi-2-Naphthol) with N- Benzylcinchonidinium Chloride. Transesterification of Phosphatidylcholine and FAME Quantification. Green Chemistry: Solventless Sequential Aldol and Michael Reactions in the Synthesis of Krohnke Pyridine. Carbonyl Chemistry in a Multistep Synthesis. Multistep Synthesis of a Bioactive Peptidomimetic. Total Synthesis of a Natural Product: Caffeic Acid Phenethyl Ester (CAPE). Appendix: Essential Laboratory Techniques.