Active Surveillance for Localized Prostate Cancer

Laurence Klotz, MD, FRCSC, CM Professor of Surgery, University of Toronto Sunnybrook Health Sciences Centre Toronto, Ontario, Canada

Cancer Overdiagnosis and Overtreatment.- Can We Screen and Still Reduce Overdiagnosis?.- The Role of Fear in Overdiagnosis and Overtreatment.- Ethical and Legal Considerations in Active Surveillance for Prostate Cancer.- Gleason 6 Tumors Should Still Be Labeled As Cancer.- Risk Based Selection for Active Surveillance.- Surveillance at the Margins: Management of High Volume Gleason 6, PSA > 10, or Gleason 3+4.- How Should Patients on Active Surveillance be Followed?.- Triggers for Intervention.- MR Imaging in Prostate Tumor Volume Assessment: How Accurate?.- Can MRI Replace Biopsy in Men on Surveillance?.- Tissue Based Markers for Risk Prediction.- International AS Registry:  The Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance Initiative.- Better Informed Decision Making to Optimize Patient Selection.- How Does QOL Compare Between Surveillance and Active Treatment?.- The Potential Benefits of Diet and Physical Activity among Active Surveillance Patients with Low-Burden Prostate Cancer.- Is there a Role for Pharmacologic Manipulation to Prevent Progression in Men on Active Surveillance?  The Role of 5-ARIs, Statins, and Metformin.- The Update of Active Surveillance around the World: Utilization and Outcomes.- Tissue Preservation - Active Surveillance and Focal Therapy as Complimentary Strategies.- The Economics of Active Surveillance for Prostate Cancer.- Research Questions in Active Surveillance.

"This is the second edition of a comprehensive review of the role of active surveillance in management of patients with localized prostate cancer. ... The book is invaluable for any urologists managing patients with prostate cancer. It is extremely helpful in understanding the concept, applications, and various challenges in managing patients placed on active surveillance. ... This book is a necessary part of any practicing urologist's library." (Mohamed T. Ismail, Doody's Book Reviews, January, 2018)