Fetal & Neonatal Hematology, Oncology and Immunology

MR Lokeshwar MD DCH Consultant Paediatrician and Paediatric Hematologist, Shushrusha Citizens Co-Operative Hospital, Lilavati Hospital and Research Centre, Mumbai, Maharashtra, India Anupam Sachdeva Director, Paediatric Hematology, Oncology and Bone Marrow Transplantation, Institute for Child Health, Sir Ganga Ram Hospital, New Delhi, India

Section 1: Fetal Hematology and Antenatal Diagnosis of Hematological Disorders





Physiology of Hematopoiesis
Developmental Hemostasis and Physiology ofHemostasis in the Fetus and the Newborn
Granulocytes: Development and Physiology
Developmental Aspects of Platelets
Fetal Anemia
Thalassemia in the Fetus: Prenatal Diagnosis
Genetic Counseling for Hematological Disorders
Fetal Hematological Disorders: Future Ahead


 



Section 2: RBC Disorders and Anemia in Newborn





Developmental Erythropoiesis
Normal Hematological Values and Variation in Newborn Periodwith Special Reference to Hb and RBC Parameters
Effect of Nutritional Deficiency Anemia duringPregnancy on Fetus and Newborn
Anemia of Prematurity
Clinical Aspect of Immune Hemolytic Disease of Newborn
Laboratory Management of ABO and Rh HemolyticDisease of the Fetus and Newborn
Nonimmune Hemolytic Anemia
Inherited Bone Marrow Failure Syndromes
Polycythemia and Hyperviscosity Syndrome in Newborn


 



Section 3: Coagulation Disorders in Newborn





Congenital Coagulation Disorders in the Neonate
Vitamin K Deficiency Bleeding
Disseminated Intravascular Coagulation in the Neonatal Period
Thrombophilia in Newborns


 



Section 4: Platelets, Platelet Disorders and Approach to Bleeding in Newborn





Approach to Neonatal Thrombocytopenia
Neonatal Thrombocytopenia: Syndromic Causes
Qualitative Platelet Disorders
Approach to a Bleeding Neonate


 



Section 5: Neutrophil Disorders





Neutrophilia
Important Causes of Neutropenia Including Inherited Conditions:Diagnosis and Work-up
Neutrophil Function Defects
Management of Neutropenia and Infections


 



Section 6: Fetal and Neonatal Malignancy





Cancers in Infants
Neonatal Leukemia
Neonatal Liver Tumor
Neuroblastoma
Renal Tumors in Neonates
Neonatal Soft Tissue Sarcomas
Fetal and Neonatal Germ Cell Tumors
Retinoblastoma and its Prenatal Screening
Pharmacology of Anticancer Drugs in Neonate
Challenges in Neonatal Malignancies


 



Section 7: Blood Transfusion (Component Therapy) and Supportive Therapy





Cellular Blood Components in Neonatal Practice
Plasma and Its Derivatives
Technical Aspects of Blood and Blood Components Transfusion including Leukodepletion and Irradiation
Risk of Transfusion in Fetus and Neonate
Hematological Growth Factors as Supportive Therapy


 



Section 8: Immunological Disorders





Introduction to Immunology
Fetal and Neonatal Immunity
Infections in Neonatal Period: Primary Immunodeficiency Perspective
Approach to Newborns with Immunodeficiency
Neutrophil Functions and Disorders of Neutrophils in Newborns
Combined T- and B-Cell Defects
Primary Antibody Deficiencies
Combined Immunodeficiencies with Associated or Syndromic Features
Immune Dysregulation Syndromes
Complement Disorders
Autoinflammatory Syndromes
Management of Specific Immunodeficiencies
Neonatal Screening and Prenatal Diagnosis of Primary Immunodeficiency Disorders


 



Index