Inflammatory Bowel Diseases (eBook)

Ashwin N. Ananthakrishnan MD, MPH, Assistant Professor of Medicine, Harvard Medical School; Director, Crohn's and Colitis Center, Massachusetts General Hospital, Boston, MA, USA. Ramnik J. Xavier MD, Kurt Isselbacher Professor of Medicine, Harvard Medical School; Chief of Gastroenterology, Massachusetts General Hospital; Institute Member, Broad Institute of MIT and Harvard, Boston, MA, USA. Daniel K. Podolsky MD, President, University of Texas Southwestern Medical Center; Professor of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX, USA.

Title Page 3
Copyright Page 4
Contents 5
Preface 11
Section I Pathogenesis and Clinical Features 13
Chapter 1 Epidemiology and Pathogenesis 15
Clinical Take Home Messages 15
Epidemiology 15
Pathogenesis 18
Genetics 18
Microbiome 20
Environmental Triggers 21
Case Studies and Multiple Choice Questions 24
References 25
Answers to Questions 27
Chapter 2 Clinical Features and Diagnosis of Crohn’s Disease 29
Clinical Take Home Messages 29
Clinical Features 31
Disease Course and Natural History 32
Diagnosis 33
History and Physical Examination 33
Laboratory Investigations 34
Serologic Markers 35
Endoscopy 35
Histology 37
Imaging Studies 37
Case Studies and Multiple Choice Questions 39
References 40
Answers to Questions 43
Chapter 3 Clinical Features and Diagnosis of Ulcerative Colitis 45
Clinical Take Home Messages 45
Clinical Features 46
Disease Course and Natural History 47
Diagnosis 47
History and Physical Examination 48
Laboratory Investigations 48
Serologic Markers 49
Endoscopy 49
Histology 51
Imaging Studies 52
Differential Diagnosis (UC and CD) 52
Case Studies and Multiple Choice Questions 56
References 57
Answers to Questions 59
Chapter 4 Extraintestinal Manifestations of Inflammatory Bowel Diseases 61
Clinical Take Home Messages 61
Arthritis and Arthropathy 62
Metabolic Bone Disease 63
Cutaneous Manifestations 64
Hepatobiliary Manifestations 65
Ophthalmologic Manifestations 67
Renal Complications 67
Thromboembolic and Cardiovascular Complications 68
Case Studies and Multiple Choice Questions 69
References 70
Answers to Questions 73
Section II Therapeutic Agents 75
Chapter 5 Aminosalicylates 77
Clinical Take Home Messages 77
Efficacy in Ulcerative Colitis 78
Efficacy in Crohn’s Disease 80
Safety 80
Multiple Choice Questions 82
References 83
Answers to Questions 85
Chapter 6 Corticosteroids 87
Clinical Take Home Messages 87
Efficacy in Ulcerative Colitis 88
Efficacy in Crohn’s Disease 89
Safety 90
Case Studies and Multiple Choice Questions 92
References 93
Answers to Questions 95
Chapter 7 Immunomodulators 97
Clinical Take Home Messages 97
Thiopurines 97
Efficacy in Ulcerative Colitis 99
Efficacy in Crohn’s Disease 100
Safety 101
Methotrexate 102
Efficacy in Ulcerative Colitis 102
Efficacy in Crohn’s Disease 103
Safety 103
Calcineurin Inhibitors 103
Efficacy in Ulcerative Colitis 103
Efficacy in Crohn’s Disease 105
Case Studies and Multiple Choice Questions 106
References 107
Answers to Questions 111
Chapter 8 Biologic Therapies 113
Clinical Take Home Messages 113
Infliximab 114
Efficacy in Ulcerative Colitis 114
Efficacy in Crohn’s Disease 117
Safety 120
Adalimumab 122
Efficacy in Ulcerative Colitis 122
Efficacy in Crohn’s Disease 123
Certolizumab Pegol 124
Efficacy in Crohn’s Disease 125
Golimumab 125
Natalizumab 125
Vedolizumab 126
Newer Therapies 127
Case Studies and Multiple Choice Questions 128
References 129
Answers to Questions 133
Chapter 9 Antibiotics 135
Clinical Take Home Messages 135
Efficacy in Ulcerative Colitis 135
Efficacy in Crohn’s Disease 136
Other Microbial Modification Methods – Probiotics and Fecal Microbiota Transplantation 137
Multiple Choice Questions 138
References 139
Answers to Questions 141
Section III Management 143
Chapter 10 Medical Management of Ulcerative Colitis 145
Clinical Take Home Messages 145
Assessment of Extent, Activity, and Severity 145
Limited Colitis – Proctitis, Proctosigmoiditis, and Left-sided Colitis 147
Pancolitis 148
Mild to Moderate Disease 149
Moderate to Severe Disease 150
Severe Disease 152
Case Studies and Multiple Choice Questions 154
References 156
Answers to Questions 158
Chapter 11 Medical Management of Crohn’s Disease 161
Clinical Take Home Messages 161
Mild to Moderate Disease 162
Moderate to Severe Disease 163
Case Studies and Multiple Choice Questions 166
References 168
Answers to Questions 169
Chapter 12 Surgical Management of Inflammatory Bowel Diseases 171
Clinical Take Home Messages 171
Surgery for Ulcerative Colitis 171
Pouch-related Complications in Ulcerative Colitis 173
Surgery for Crohn’s Disease 175
Prophylaxis for Prevention of Postoperative Recurrence in Crohn’s Disease 176
Case Studies and Multiple Choice Questions 179
References 180
Recommended Reading 181
Answers to Questions 182
Chapter 13 Complications of Inflammatory Bowel Diseases 183
Clinical Take Home Messages 183
Complications of Ulcerative Colitis 184
Toxic Megacolon and Perforation 184
Colonic Strictures 185
Clostridium difficile and Cytomegalovirus Colitis 185
Colorectal Dysplasia and Cancer 186
Magnitude and Risk Factors 186
Surveillance for Dysplasia and Cancer 187
Management of Dysplasia 187
Chemoprevention 188
Complications of Crohn’s Disease 188
Fibrostenosis and Strictures 188
Abscesses 189
Fistulizing Crohn’s Disease 190
Small-bowel Cancer 193
Case Studies and Multiple Choice Questions 194
References 196
Answers to Questions 199
Section IV Special Considerations 201
Chapter 14 Nutrition in Inflammatory Bowel Diseases 203
Clinical Take Home Messages 203
Malnutrition and Micronutrient Deficiencies 203
Dietary Therapies for Inflammatory Bowel Diseases 205
Case Studies and Multiple Choice Questions 206
References 207
Answers to Questions 209
Chapter 15 Pregnancy, Conception, and Childbirth 211
Clinical Take Home Messages 211
Fertility 211
Effect of Pregnancy on Disease 212
Effect of Disease on Pregnancy 212
Maternal Medication Use During Pregnancy 213
Paternal Medication Use 215
Inheritance 215
Case Studies and Multiple Choice Questions 216
References 217
Answers to Questions 219
Chapter 16 Inflammatory Bowel Disease During Childhood and Adolescence 221
Clinical Take Home Messages 221
Epidemiology and Clinical Features 221
Treatment of Pediatric Inflammatory Bowel Disease 222
Very Early-onset Inflammatory Bowel Disease 223
Transition of Care in Pediatric Crohn’s Disease 223
Case Studies and Multiple Choice Questions 225
References 226
Answers to Questions 228
Index 229
EULA 235

"This is a valuable book that everybody taking care of IBD patients should have. It is very concise but at the same time very complete" Henrique Fernandez, MD, FACP, Parkview Medical Center on behalf of Doody's