Natural Products Targeting Clinically Relevant Enzymes

PAULA B. ANDRADE is Associate Professor at the Faculty of Pharmacy of the University of Porto. As head of the Pharmacognosy lab, she also coordinates the natural products group of the REQUIMTE/LAQV, an institute active in Green Chemistry, and evaluates research projects for various international entities. Her research on bioactive substances originating from matrices of marine and terrestrial origin was published in more than 30 book chapters and more than 300 articles in international journals. PATRICIA VALENTÃO obtained her PhD in Pharmaceutical Sciences at the University of Porto for work on pharmacognosy. She was appointed Assistant Professor at the Faculty of Pharmacy, University of Porto in 2007. Her research focuses on qualitative and quantitative metabolite profiling of terrestrial and marine natural matrices with the goal to reveal composition/activity relationships of these compounds in various clinically-relevant areas. Patricia Valentão is member of the REQUIMTE/LAQV Institute of Green Chemistry and editorial board member of the "EJournal of Chemistry". She (co)authored more than 30 book chapters and more than 250 articles in international journals. DAVID M. PEREIRA obtained his PhD in Pharmaceutical Sciences at the University of Porto for work on phytochemistry and pharmacognosy. In 2014 he was appointed Assistant Professor at the Faculty of Pharmacy of the same university. David Pereira edited one book, contributed more than 20 book chapters and over 60 papers covering research areas of natural products, inflammation, drug discovery and analytical techniques. He also serves in the Editorial Board of several journals related to natural products and analytical techniques. He is appointed expert in the "Global Burden of Disease" program of the University of Washington, and reviewer/consultant in Biomedical Sciences for several European institutions.

Natural products as enzyme inhibitors
Natural ACE inhibitors with antihypertensive properties
Hypoglycaemic effects of plants food constituents via inhibition of carbohydrate-hydrolysing enzymes: from chemistry to future applications.
Natural Product Inhibitors of Cyclooxygenase (COX) Enzymes: Current Status and Future Perspective
Natural Products Targeting Clinically Relevant Enzymes of Eicosanoid Biosynthesis implicated in inflammation and cancer
Natural inhibitors of mitochondrial respiratory chain: therapeutic and toxicological implications
Angiotensin-I-Converting enzyme (ACE-I) inhibitors from marine bio-resources
Refreshing the Marine-derived Chemotherapeutic Pipeline
Recent developments on the natural products and their derivatives targeting PfDHFR (Dihydrofolate reductase) and PfHSP (Heat sensitive protein)
Phospholipase A2 inhibitors of marine origin: a target for inflammation
Natural Plant-derived Acetylcholinesterase Inhibitors: Relevance for Alzheimer's disease
Molecular Targets of Clinically-Relevant Natural Products from Filamentous Marine Cyanobacteria
Natural inhibitors of beta-secretase
Anti-HIV natural products