Diastolic Relaxation of the Heart

I. Molecular Biology of Relaxation.- 1. Overview: The Molecular Phenotype of Normal and Impaired Relaxation.- 2. Regulation of Gene Expression in the Failing Myocardium: Evidence for a Heart Failure Gene Program.- 3. Sarcoplasmic Reticulum Gene Expression in Human Heart Failure.- 4. Molecular Aspects of the Control of Myocardial Relaxation.- 5. Molecular Physiology of Ventricular Hypertrophy.- II. Consequences of Altered Gene Expression: The Economy of Diastole.- 6. Regulatory Proteins and Diastolic Relaxation.- 7. Intracellular Free Calcium in Hypertrophy and Failure.- 8. A Molecular Biophysical Approach to Contraction and Relaxation.- 9. On the Relations Among ATP Hydrolysis, Cation Accumulation, and Diastolic Dysfunction.- 10. Adrenergic Signal Transduction in Congestive Heart Failure: Effects on Diastole.- 11. Cardiac Renin-Angiotensin System in Cardiac Hypertrophy and Failure.- 12. Altered Force-Frequency Relation and Excitation-Contraction Coupling in the Failing Human Heart. Relevance of SR-Ca2+-ATPase Protein Levels.- III. Impaired Relaxation in Experimental Models: Ischemia and Hypoxia.- 13. Effects of Hypoxia and Ischemia on Intracellular Calcium and Relaxation: Studies in the Aequorin-Loaded Whole Heart Model.- 14. Diastolic Dysfunction During Ischemia: Role of Glycolytic ATP Generation.- 15. Does Calcium Overload Adequately Explain Diastolic Dysfunction during Metabolic Inhibition?.- 16. Mechanisms of Relaxation: Perspectives from Studies in Single Cardiac Cells.- 17. Modulation of Diastolic Dysfunction in the Intact Heart.- 18. Altered Load: An Important Component of Impaired Diastolic Function in Hypertension and Heart Failure.- 19. Endothelial-Ventricular Interaction in Normal and Diseased Hearts.- IV. Impaired Relaxation in Experimental Models: Hypertrophy and Failure.- 20. Diastolic Dysfunction in Experimental Heart Failure.- 21. Interplay of Hypertrophy and Myocardial Ischemia.- 22. Myocardial Fibrosis: Structural Basis for Diastolic Dysfunction.- 23. Coronary Venous Pressure and Left Ventricular Diastolic Distensibility.- 24. Pericardium and Ventricular Interaction: Effects on Diastolic Filling.- 25. Diastolic Dysfunction in Tachycardia- Induced Heart Failure.- 26. Diastolic Abnormalities in Low-Flow and Pacing Tachycardia-Induced Ischemia in Isolated Rat Hearts — Modification by Calcium Antagonists.- V. Diastolic Dysfunction in The Diseased Human Heart.- 27. Diastolic Dysfunction and Myocardial Energetics.- 28. Diastolic Dysfunction in Chronic Pressure and Volume Overload.- 29. Sustained Diastolic Dysfunction Following Severe Exercise-Induced Ischemia in Patients with Coronary Disease.- 30. Exercise Intolerance in Patients with Heart Failure: Role of Diastolic Dysfunction.- 31. Comparative Effects of Ischemia and Hypoxemia on Left Ventricular Diastolic Function in Humans.- 32. Determinants of Left Ventricular Diastolic Filling: Insights from Echo-Doppler.