Practical Transfusion Medicine

Michael F. Murphy, Consultant Haematologist, NHS Blood & Transplant and Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, and Professor of Blood Transfusion Medicine, University of Oxford, UK

David J. Roberts, Professor of Haematology, University of Oxford, UK

Mark H. Yazer, Professor of Pathology, University of Pittsburgh, USA

List of Contributors ix

Preface xv

1 Introduction: Two Centuries of Progress in Transfusion Medicine 1
Walter H. (Sunny) Dzik and Michael F. Murphy

Part I
Basic Principles of Immunohaematology 11
2 Essential Immunology for Transfusion Medicine 11
Jaap Jan Zwaginga and S. Marieke van Ham
3 Human Blood Group Systems 20
Geoff Daniels
4 Human Leucocyte Antigens 29
Cristina V. Navarrete and Colin J. Brown
5 Platelet and Neutrophil Antigens 43
Brian R. Curtis
6 Pretransfusion Testing and the Selection of Red Cell Products for Transfusion 58
Mark H. Yazer and Meghan Delaney

Part II Complications of Transfusions 69
7 Investigation of Acute Transfusion Reactions 69
Kathryn E. Webert and Nancy M. Heddle
8 Haemolytic Transfusion Reactions 81
Edwin J. Massey, Robertson D. Davenport and Richard M. Kaufman
9 Febrile and Allergic Transfusion Reactions 97
Mark K. Fung and Nancy M. Heddle
10 Lung Injury and Pulmonary Oedema After Transfusion 108
Steven H. Kleinman and Daryl J. Kor
11 Purported Adverse Effects of 'Old Blood' 118
Lirong Qu and Darrell J. Triulzi
12 Transfusion?]Induced Immunomodulation 125
Amy E. Schmidt, Majed A. Refaai, Joanna M. Heal and Neil Blumberg
13 Transfusion?]Associated Graft?]Versus?]Host Disease and Microchimerism 136
Beth H. Shaz, Richard O. Francis and Christopher D. Hillyer
14 Posttransfusion Purpura 147
Michael F. Murphy
15 Transfusion?]Transmitted Infections 153
Roger Y. Dodd and Susan L. Stramer
16 Bacterial Contamination 168
Sandra Ramírez?]Arcos and Mindy Goldman
17 Emerging Infections and Transfusion Safety 176
Roger Y. Dodd

Part III Practice in Blood Centres and Hospitals 184
18 Regulatory Aspects of Blood Transfusion 184
William G. Murphy, Louis M. Katz and Peter Flanagan
19 The Role of Haemovigilance in Transfusion Safety 193
Katharine A. Downes and Barbee I. Whitaker
20 Donors and Blood Collection 203
Marc Germain, Ellen McSweeney and William G. Murphy
21 Blood Donation Testing and the Safety of the Blood Supply 215
Mindy Goldman
22 Production and Storage of Blood Components 222
Marissa Li, Rebecca Cardigan, Stephen Thomas and Ralph Vassallo
23 Blood Transfusion in Hospitals 233
Erica M. Wood, Mark H. Yazer and Michael F. Murphy
24 Blood Transfusion in a Global Context 254
David J. Roberts, Alan D. Kitchen, Stephen P. Field, Imelda Bates, Jean Pierre Allain and Meghan Delaney

Part IV Clinical Transfusion Practice 264
25 Inherited and Acquired Coagulation Disorders 264
Irina Chibisov and Franklin Bontempo
26 Massive Blood Loss 279
John R. Hess
27 Blood Management in Acute Haemorrhage and Critical Care 287
Gavin J. Murphy, Nicola Curry, Nishith N. Patel and Timothy S. Walsh
28 Point?]of?]Care Testing in Transfusion Medicine 302
Matthew D. Neal and Louis H. Alarcon
29 Haematological Disease 312
Lise J. Estcourt, Simon J. Stanworth and Michael F. Murphy
30 Blood Transfusion in the Management of Patients with Haemoglobinopathies 330
Enrico M. Novelli
31 Heparin?]Induced Thrombocytopenia 341
Andreas Greinacher and Theodore E. Warkentin
32 Immunodeficiency and Immunoglobulin Therapy 357
Siraj A. Misbah
33 Transfusing Neonates and Infants 371
Ronald G. Strauss

Part V Patient Blood Management 383
34 Development of a Patient Blood Management Programme 383
Jonathan H. Waters
35 Perioperative Patient Blood Management 393
Martin Rooms, Ravishankar Rao Baikady and Toby Richards
36 Restrictive Transfusion Practice and How to Implement It 405
Lawrence Tim Goodnough and Neil Shah
37 Using Data to Support Patient Blood Management 416
Steven M. Frank and Jack O. Wasey

Part VI Cellular and Tissue Therapy and Organ Transplantation 429
38 Regulation and Accreditation in Cellular Therapy 429
Zbigniew (Ziggy) M. Szczepiorkowski and Daniel Hollyman
39 Stem Cell Collection and Therapeutic Apheresis 442
Khaled El?]Ghariani and Zbigniew (Ziggy) M. Szczepiorkowski
40 Haemopoietic Stem Cell Processing and Storage 455
Hira Mian, Ronan Foley and Pamela O'Hoski
41 Haematopoietic Stem Cell Transplantation 466
Robert D. Danby, Rachel Protheroe and David J. Roberts
42 Cord Blood Transplantation 477
Rachael Hough and Robert D. Danby
43 Recent Advances in Clinical Cellular Immunotherapy 490
Mark W. Lowdell and Emma Morris
44 Tissue Banking 500
Akila Chandrasekar, Paul Rooney and John N. Kearney

Part VII Development of the Evidence Base for Transfusion 508
45 Observational and Interventional Trials in Transfusion Medicine 508
Alan T. Tinmouth, Dean Fergusson and Paul C. Hébert
46 Getting the Most Out of the Evidence for Transfusion Medicine 520
Simon J. Stanworth, Susan J. Brunskill, Carolyn Dorée and Sally Hopewell
47 A Primer on Biostatistics 533
Andrew W. Shih and Nancy M. Heddle
48 A Primer on Health Economics 549
Seema Kacker and Aaron A. R. Tobian
49 Scanning the Future of Transfusion Medicine 560
Jay E. Menitove, Paul M. Ness and Edward L. Snyder
Index 572