Scleroderma (eBook)

From Pathogenesis to Comprehensive Management
eBook Download: PDF
2016 | 2nd ed. 2017
XXXV, 743 Seiten
Springer International Publishing (Verlag)
978-3-319-31407-5 (ISBN)

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Comprised of the authoritative work of international experts, this fully-updated second edition of Scleroderma builds upon the well-regarded approach in the first edition to provide integrated, concise, and up-to-date synthesis of current concepts of pathogenesis and modern approaches to management of systemic sclerosis (scleroderma). With a multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. The new edition includes extensive updated material based on major developments in the field, with new chapters on personalized medicine, cancer complications, global perspectives on scleroderma, and more. It presents a succinct and thoughtful synthesis of current pathomechanistic concepts, providing a valuable reference tool for basic and translational investigators working in the field. Scleroderma: From Pathogenesis to Comprehensive Management serves as an essential, all-inclusive resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.



John Varga, MD

John and Nancy Hughes Distinguished Professor

Feinberg School of Medicine

Director, Northwestern Scleroderma Program

Chicago, Illinois, USA​

 

Christopher P. Denton, PhD, FRCP

Professor of Experimental Rheumatology

Centre for Rheumatology and Connective Tissue Diseases

Division of Medicine

University College London

London, United Kingdom

 

Fredrick M. Wigley, MD

Martha McCrory Professor of Medicine

Department of Medicine/Rheumatology

The Johns Hopkins University School of Medicine

Baltimore, Maryland, USA

 

Yannick Allanore, MD

Service de Rhumatologie A

Université Paris Descartes,

Hôpital Cochin

Paris, France

 

Masataka Kuwana, MD, PhD

Professor

Department of Allergy and Rheumatology

Nippon Medical School Graduate School of Medicine

Tokyo, Japan

John Varga, MD John and Nancy Hughes Distinguished Professor Feinberg School of Medicine Director, Northwestern Scleroderma Program Chicago, Illinois, USA​   Christopher P. Denton, PhD, FRCP Professor of Experimental Rheumatology Centre for Rheumatology and Connective Tissue Diseases Division of Medicine University College London London, United Kingdom   Fredrick M. Wigley, MD Martha McCrory Professor of Medicine Department of Medicine/Rheumatology The Johns Hopkins University School of Medicine Baltimore, Maryland, USA   Yannick Allanore, MD Service de Rhumatologie A Université Paris Descartes, Hôpital Cochin Paris, France   Masataka Kuwana, MD, PhD Professor Department of Allergy and Rheumatology Nippon Medical School Graduate School of Medicine Tokyo, Japan

Section I. Introduction.- Historical Perspective of Scleroderma.- Section II. Epidemiology, Genetics and Classification.- Epidemiology, Environmental and Infectious Risk Factors.- Genetic Factors.- Disease Subsets in Clinical Practice.- Evolving Concepts of Diagnosis and Classification.- Overlap Syndromes.- Juvenile Localized and Systemic Scleroderma.- Morphea (Localized Scleroderma).- Scleroderma Mimics.- Systems Biology Approaches to Understanding the Pathogenesis of Systemic Sclerosis.- Section III: The Biological Basis of Systemic Sclerosis.- Introduction: The Etiopathogenesis of Systemic Sclerosis: An Integrated Overview.- Pathology of Systemic Sclerosis.- Inflammation and Immunity.- Autoantibodies as Markers and Possible Mediators of Scleroderma Pathogenesis.- The Clinical Aspects of Autoantibodies.- Mechanisms of Vascular Disease.- Biomarkers in Systemic Sclerosis.- Pathophysiology of Fibrosis in Systemic Sclerosis.- Overview of Animal Models.- Section IV. Cardiovascular Manifestations and Management.- Raynaud’s Phenomenon, Digital Ulcers, and Nailfold Capillaroscopy.- Renal Crisis and Other Renal Manifestations of Scleroderma.- Cardiac Involvement.- Section V. Pulmonary Manifestations and Management.- Overview of Lung Involvement: Diagnosis, Differential Diagnosis, and Monitoring.- Clinical Assessment of Lung Disease.- Treatment of Interstitial Lung Disease.- Pathogenesis of Pulmonary Arterial Hypertension.- Clinical Assessment of Pulmonary Hypertension.- The Management of Pulmonary Arterial Hypertension in the Setting of Systemic Sclerosis.- Section VI. Gastrointestinal Manifestations and Management.- Overview of Gastrointestinal Tract Involvement.- Upper Gastrointestinal Tract: Manifestations of Systemic Sclerosis.- Small and Large Intestinal Involvement and Nutritional Issues.- Section VII. Skin, Musculoskeletal and Other Complications.- Calcinosis.- Evaluation and Management of Skin Disease.- Assessment and Management of Progressive Skin Involvement in Diffuse Scleroderma.- Skeletal Muscle Involvement.- Tendons, Joints, and Bone.- Cancer in Systemic Sclerosis.- Overlooked  Manifestations.- Pregnancy.- Section VIII:  Management and Outcome Assessment.- Introduction to Section VIII: Management and Outcome Assessment.- Immunomodulatory, Immunoablative, and Biologic Therapies.- Investigative Approaches to Drug Therapy.- Drug Development and Regulatory Considerations for SSc Therapies.- Physical and Occupational Therapy.- Psychosocial Issues and Care for Patients with Systemic Sclerosis.- Clinical Trial Design in Systemic Sclerosis.- Measuring Disease Activity and Outcomes in Clinical Trials.- Innovative Approaches to Clinical Trials in Systemic Sclerosis.- Molecular Stratification by Gene Expression as a Paradigm for Precision Medicine in Systemic Sclerosis.- Section IX. Case Studies: Approach to Complex Clinical Problems.- Managing the Ischemic Finger in Scleroderma.- Scleroderma Renal Crisis.- Rapid Diffuse Skin Disease with Progressive Joint Contractures.- Management of the Scleroderma Patient with Pulmonary Arterial Hypertension Failing Initial Therapy.- Pseudo-obstruction with Malabsorption and Malnutrition.- Progressive Interstitial Lung Disease Non-Response to Cyclophosphamide.- Coping with the Disfigurement of Scleroderma: Facial, Skin, and Hand Changes.- Managing Complicated Digital Ulcers 

Erscheint lt. Verlag 7.11.2016
Zusatzinfo XXXV, 743 p. 191 illus., 174 illus. in color.
Verlagsort Cham
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Dermatologie
Medizinische Fachgebiete Innere Medizin Pneumologie
Schlagworte Autoimmune • Fibrosis • Pulmonary hypertension • scleroderma • systemic sclerosis
ISBN-10 3-319-31407-6 / 3319314076
ISBN-13 978-3-319-31407-5 / 9783319314075
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