Herpes Simplex Virus

This work discusses the possible modes of development of HSV infections (herpes simplex virus), types 1 and 2, and emphasizes how various aspects of immunity are thought to control the infection or, in some cases, contribute to the development of the disease.

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Herpes simplex virus (HSV) types 1 and 2 continue to be major human pathogens against which we lack acceptable vaccines or other means of immunological control. In this volume, leading investigators discuss the possible modes of development of HSV infections and emphasize how various aspects of immunity are thought to control the infection or, in some cases, contribute to the development of diseases. The book begins with brief overview of the regulation of gene expression by HSV, followed by a series of chapters on pathogenesis and how different aspects of specific and natural immunity play a role in controlling HSV in different disease situations. The important topic of HSV as a common cause of blindness, in which the immune response appears to play a pathological role, is also discussed. The final chapters deal with current progress in developing convention vaccines against HSV and the novel approach of intracellular immunization and its possible applications to HSV.