Diabetes and Kidney Disease

EDGAR V. LERMA, MD, FACP, FASN, FAHA, FASH, FNLA, FNKF Clinical Associate Professor of Medicine Section of Nephrology Department of Medicine University of Illinois at Chicago College of Medicine/ Associates in Nephrology, S.C.

 
Background-History
 
Part I:  Natural Course, Pathogenesis, Morphology and Genetics
 
1.   Diabetic Nephropathy—Scope of the problem (Epidemiology, US, Japan, Europe, Obesity (Metabolic Syndrome) Geriatrics
2.   Natural Course (Stages/Evidence Based Discussion)
3.   Pathogenesis: Biochemical and functional alterations involving the  GBM and mesangium
4.  Pathogenesis: Hemodynamic alterations/renin angiotensin system
5.   Renal structural damage in type 1 and type 2 DM
6.   Diabetes in children and adolescents
7.  Genetic markers and predictors of DN
 
Part II:  Clinical Presentation and Associated Disorders
 
8. Screening and early diagnosis (E. Cohen – Milwaukee)
9. Differential diagnosis of proteinuria in DM (A. Reddi, NJ Med Sch)
10. Hypertension in DM
11. Cardiovascular Disease (L. Hamm, Tulane)
12.  Lipid disorders
13.  Eye complications in DN (Z. Karcioglu, U. Virginia)
14. Pregnancy and DN (K. Krane—Tulane)
15. Transplantation: Kidney, Kidney-Pancreas (R. Zhang)
 
Part III:  Treatment and Prognosis
 
16. Glycemic control
17.  BP control in hypertensive diabetics with proteinuria
18. Early antihypertensive treatment in early stages of DN
19. Lifestyle modifications
20. Novel treatments (stem cells, islet cell transplants, gene transfer, etc.)
 
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