Essentials of Apoptosis

I. Molecules and Pathways of Apoptosis.- Caspases: Activation, Regulation, and Function.- The Bcl-2 Family Proteins.- The Mammalian IAPs: Multifaceted Inhibitors of Apoptosis.- Structural Biology of Programmed Cell Death.- The Death Receptor Pathway.- The Mitochondrial Pathway: Focus on Shape Changes.- The Endoplasmic Reticulum Pathway.- Reactive Oxygen Species in Cell Fate Decisions.- The Integration of Metabolism and Cell Death.- Transcriptional Regulation of Apoptosis.- Clearance of Apoptotic Cells – Mechanisms and Consequences.- Systems Biology Approaches to the Study of Apoptosis.- II: Apoptosis in Model Organisms.- Programmed Cell Death in Plants: Apoptotic but Not Quite.- Tracing the Roots of Death: Apoptosis in Saccharomyces cerevisiae.- Programmed Cell Death in C. elegans.- Cell Death in Drosophila.- III. Apoptosis in Mammalian Physiology and Pathogenesis.- Cell Death: Defining and Misshaping Mammalian Embryos.- Matters of Life and Death in the Immune System.- Cell Death in the Hematopoietic System.- Cell Death in Acute Neuronal Injury.- Apoptosis in Neurodegenerative Diseases.- Apoptosis in Cardiovascular Pathogenesis.- Apoptosis in Lung Injury and Disease.- Apoptosis in Liver Injury and Liver Diseases.- Apoptosis in Acute Kidney Injury.- Apoptosis in Cancer Biology and Cancer Therapeutics.- IV. Alternative cell death mechanisms and pathways.- Necrosis: Molecular Mechanisms and Physiological Roles.- Caspase-Independent Mitotic Death.- Lysosomal Proteases in Cell Death.- Autophagy and Cell Death.- V. Approaches to the study of apoptosis.- Analysis of Apoptosis: Basic Principles and Protocols.