An Introduction to Pain and its relation to Nervous System Disorders (eBook)

Dr Anna A. Battaglia, School of Biomedical Sciences, King's College London, Currently a Lecturer in the Department of Anatomy & Human Sciences at King's College London. Research interests include: Chronic pain; Eph Receptors and ephrins; Biopsychosocial models of chronic pain. Her research experience has led her to developing new ideas in the pedagogy of Neuroscience and of scientific disciplines in general. She runs a third year undergraduate module called: Perspectives on Nervous System disorders. I am also setting up a "Pain Scenario" for MBBS2 students on the Neurobiology of Pain and on the interdisciplinary management of chronic pain syndromes, with the aim to fill a gap in the undergraduate medical education.

List of contributors ix

Foreword xiii

Acknowledgements xv

Notes on authors xvii

Introduction 1
Anna A. Battaglia

Section I: Neurobiology of pain: Recent advances 11

1 Anatomy of pain pathways 13
Andrew J. Todd

2 Spinal plasticity of the nociceptive system: The role of central sensitisation in chronic pain states 35
Alban Latrémolière

3 Symptoms and pathology in neuropathic pain 89
Matthew Thakur and Stephen B. McMahon

4 Recent advances in neuroimmune interactions in neuropathic pain: The role of microglia 123
Elizabeth A. Old, Louise S. C. Nicol and Marzia Malcangio

5 Genetics and epigenetics of pain 149
Franziska Denk and Stephen B. McMahon

6 The cannabinoid system and its role in nociception 169
Massimiliano Beltramo

7 EphB receptors and persistent pain 201
Isabella Gavazzi

Section II: Pain in the brain 225

8 Brain imaging in experimental pain 227
Massieh Moayedi and Tim V. Salomons

9 Placebo effects in pain 249
Luana Colloca, Adam P. Horin and Damien Finniss

10 Psychology and pain 267
Lance M. McCracken

Section III: Pain in the lifecycle and in nervous system disorders 281

11 Pain in neonates and infants 283
Fiona Moultrie, Segzi Goksan, Ravi Poorun and Rebeccah Slater

12 How do people with autism spectrum disorders (ASD) experience pain? 295
Cecile Rattaz, Amandine Dubois and Amaria Baghdadli

13 Pain and depression: The janus factor of human suffering 317
Angela Iannitelli and Paola Tirassa

14 Pain in multiple sclerosis: From classification to treatment 345
Claudio Solaro and Michele Messmer Uccelli

15 Pain perception in dementia 361
Miriam Kunz and Stefan Lautenbacher

16 The role of cognitive impairment in the placebo and nocebo effects 373
Martina Amanzio

17 An overview of pain in Parkinson's disease 387
Panagiotis Zis, Elisaveta Sokolov and Kallol Ray Chaudhuri

Appendix: Interviews with chronic pain patients 409

Index 413