Post-Traumatic Arthritis (eBook)

Steven A. Olson, MD, Professor, Duke University Medical Center, Department of Orthopaedic Surgery, Durham, NC, USAFarshid Guilak, PhD, Laszlo Ormandy Professor, Duke University Medical Center, Department of Orthopaedic Surgery, Durham, NC, USA

​Section I: The Problem of Post-Traumatic Arthritis.- Arthritis that Develops after Joint Injury: Is it Post-Traumatic Arthritis or Post-Traumatic OsteoArthritis?.- Post-Traumatic Arthritis: Definitions and Burden of Disease.- Arthritis after Joint Injury: The Military Experience.- Section II: Experimental Models of Joint Injury.- In Vitro Cartilage Explant Injury Models.- Animal Models of Meniscal Injury in Post-Traumatic Arthritis.-Anterior Cruciate Transection/Disruption Models of Posttraumatic Arthritis.- Closed Joint ACL Disruption Murine Model of PTA.- Whole Joint Models of Articular Injury and Articular Fracture.- Instability: Dynamic Loading Models.- Survey of Animal Models in Post-Traumatic Arthritis: Choosing the Right Model to Answer the Right Question.- Section III: Peri-articular Tissue Response to Joint Injury.- The Response of Cartilage to Injury.- The Response of Subchondral Bone to Injury.- Genetic Variability in the Response to Injury.- Aging and Post-Traumatic Arthritis.-Potential Mechanisms of PTA: Cell Death.- Potential Mechanisms of PTA: Inflammation.- Potential Mechanisms of PTA: Oxidative Stress.- Potential Mechanisms of PTA: Alterations in Joint Loading.- Section IV: Clinical Assessment and Treatment of Patients with Joint Injury.- Imaging Specific to Cartilage Injury.- Outcomes of ACL Injury: The MOON Consortium.- Current Treatment and Outcomes of Intra-articular Fractures.- Non-arthroplasty Treatments for PTA in the Lower Extremity.- Results of Arthroplasty in Post-Traumatic Arthritis.- Section V: Developing and Future Assessment and Therapies.- Measurement of Severity of Injury after Articular Fracture and Correlation with Post-Traumatic Arthritis Development.- Biomarkers of PTA.- Potential Targets for Pharmacologic Therapies for Prevention of PTA.- Stem Cells Therapies for Post-Traumatic Arthritis.- Unanswered Questions and Future Directions.