Mustard Gas Toxicity

Working Table of Contents or Outline of contents Mustard Gas Toxicity: Provisional Table of Contents (Note that the chapters will be included under the below-mentioned sections or subsections. each section will begin with introductory, 5 to 10-page passage by the editors) Preface 1. Introduction Historical survey covering the development of mustard gas (MG) and related compounds, their deployment in warfare, early and more studies on toxic mechanisms, early and more recent clinical experiences. 2. Clinical aspects I: acute effects of MG poisoning 2.1 Lungs 2.2 Skin 2.3 Eyes 2.4 Other organs 3. Clinical aspects II: chronic effects of MG poisoning 3.1 Lungs 3.2 Skin 3.3 Eyes 3.4 Immune system 3.5 Malignancies 3.6 Other organs 4. General properties of MG and similar agents 4.1 Physical properties 4.2 General chemical properties 4.3 Biochemical effects 4.4 Pharmacodynamics 5. Molecular mechanisms of toxicity 5.1 DNA damage and its consequences (PARP activation, the damage response network, stress genes, plasminogen activator) 5.2 Other mechanisms (protein cross-linking and cytoskeletal damage, oxidative stress, membrane damage, acute inflammatory response) 5.3 Consequences of TNF-alpha production (MAPK involvement, sphingomyelinase, nitric oxide, p53) 5.4 Cell death: mechanisms of apoptosis and necrosis 5.5 Involvement of reactive oxygen species and nuclear factor kappa-B 5.6 Other mechanisms 6. Relationship of molecular mechanisms to clinical effects of MG toxicity 6.1 General principles 6.2 Lungs 6.3 Skin 6.4 Eyes 6.5 Immune system 6.6 Other organs 7. Experimental models 8. Prospects for prevention and treatment of MG toxicity 8.1 General principles 8.2 Lungs 8.3 Skin 8.4 Eyes 8.5 Other organs References Subject index