Principles of Molecular Rheumatology

I. Molecular Mechanisms in Rheumatic Diseases.- 1 Genetics.- 2 Viruses.- 3 Apoptosis.- 4 Humoral Response.- 5 T-Cell Signaling.- 6 Adhesion and Costimulatory Molecules.- 7 Transcription Factors.- 8 Immune Complexes.- 9 Complement.- 10 Eicosanoids and Other Bioactive Lipids.- 11 Collagens.- II. Cellular Mechanisms in Rheumatic Diseases.- 12 T-Lymphocytes.- 13 B-Lymphocytes.- 14 Monocytes and Macrophages.- 15 Polymorphonuclear Cells.- 16 Synoviocytes.- 17 Chondrocytes.- 18 Osteoblasts and Osteoclasts.- 19 Animal Models.- III. Pathogenesis of Rheumatic Diseases.- 20 Systemic Lupus Erythematosus.- 21 Rheumatoid Arthritis.- 22 Inflammatory Myopathies.- 23 Systemic Sclerosis.- 24 Vasculitis.- 25 Osteoarthritis.- 26 Osteoporosis.- 27 Heritable Disorders of Connective Tissue.- IV. Molecular Aspects of Treatment of Rheumatic Diseases.- 28 Corticosteroids.- 29 Cytotoxic Drugs.- 30 Complement Inhibitors.- 31 Cytokine Response Modifiers.- 32 Restoration of Immune Tolerance.- 33 Metalloproteases and Their Modulation as Treatment in Osteoarthritis.- 34 Gene Therapy.