Targeted Therapy in Translational Cancer Research

Apostolia-Maria Tsimberidou, MD PhD Department of Investigational Cancer Therapeutics The University of Texas MD Anderson Cancer Center Houston, TX, USA Razelle Kurzrock Center for Personalized Cancer Therapy, UC San Diego - Moores Cancer Center La Jolla, CA, USA Kenneth C. Anderson MD LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School Boston, MA, USA

List of Contributors, vii

Series Foreword, xiii

Foreword, xv

Preface, xvii

Part I Principles of Targeted Therapies

1 Toward Personalized Therapy for Cancer, 3
Ashley M. Holder and FundaMeric-Bernstam

2 Combining Targeted Therapies, 14
Jordi Rodon, Analia Azaro, Davis Torrejon, and Razelle Kurzrock

3 Principles of Targeted Immunotherapy, 27
Susanne H. C. Baumeister and Glenn Dranoff

4 Cancer Stem Cell Principles, 39
Allison C. Sharrow, Gabriel Ghiaur, and Richard J. Jones

5 The Tumor Microenvironment as a Target for Therapeutic Intervention, 47
Hua Fang and Yves A. DeClerck

6 The Role of Angiogenesis in Cancer, 64
Morgan Taylor, Robert L. Coleman, and Anil K. Sood

7 Epigenetics and Epigenetic Therapy of Cancer, 72
Omotayo Fasan, Patrick Boland, PatriciaKropf, and Jean-Pierre J. Issa

8 The Role of microRNAs in Cancer, 80
Gianpiero Di Leva and Carlo M. Croce

9 AcuteMyeloidLeukemia, 89
Ofir Wolach and Richard M. Stone

10 Targeted and Functional Imaging, 101
Jian Q. (Michael) Yu, Drew A. Torigian, and Abass Alavi

Part II Targeted Therapy in Hematological Malignancies

11 Targeted Therapies in Chronic Myeloid Leukemia, 113
Elias Jabbour and Jorge Cortes

12 Targeted Therapy for Acute Lymphoblastic Leukemia, 121
Nitin Jain, Susan O’Brien, and Farhad Ravandi-Kashani

13 Chronic Lymphocytic Leukemia, 130
Preetesh Jain and Susan O’Brien

14 Multiple Myeloma, 145
Giada Bianchi and Kenneth C. Anderson

15 The Impact of Genomics on Targeted Therapy in Multiple Myeloma and Lymphomas, 157
Jens G. Lohr and Birgit Knoechel

16 Targeted Therapy in Myelodysplastic Syndromes, 162
Guillermo Montalb´an-Bravo and Guillermo Garc´ýa-Manero

17 Lymphoma and Targeted Therapies, 169
Sonali M. Smith and Julie M. Vose

Part III Targeted Therapy in Solid Tumors

18 Targeted Therapy in Solid Tumors: Brain, 179
Shiao-PeiWeathers, Barbara J. O’Brien, John F. de Groot, andW. K. Alfred Yung

19 Targeted Therapy for Breast Cancer, 190
Harold J. Burstein

20 Targeted Therapy in Solid Tumors: Colorectal Cancer, 193
Maen Abdelrahim, Scott Kopetz, and David Menter

21 Endometrial Cancer, 205
Jessica L. Bowser, Russell R. Broaddus, Robert L. Coleman, and Shannon N. Westin

22 Targeted Therapy in Solid Tumors: Head and Neck, 216
Marcus M. Monroe and Jeffrey N. Myers

23 Targeted Therapy in Solid Tumors: Lung Cancer, 224
Saiama N.Waqar, Daniel Morgensztern, and Roy S. Herbst

24 Targeted Therapy in Melanoma, 231
Keith T. Flaherty

25 Ovarian Cancer, 240
Shannon N.Westin, Larissa A. Meyer, and Robert L. Coleman

26 Molecular Therapeutics: Pancreatic Cancer, 255
David Fogelman, Milind Javle, and James Abbruzzese

27 Targeted Therapies for Pediatric Solid Tumors, 263
Jasmine Quynh Dao and Patrick A. Zweidler-McKay

28 Prostate Cancer, 273
William G. Nelson, Michael C. Haffner, and Srinivasan Yegnasubramanian

29 Renal Cell Carcinoma and Targeted Therapy, 287
Benjamin A. Gartrell, Alexander C. Small, William K. Oh, and Matthew D. Galsky

30 Targeted Therapy in Solid Tumors: Sarcomas, 296
Anthony P. Conley, Vinod Ravi, and Shreyaskumar Patel

Part IV Targeted Therapy for Specific Molecular Aberrations

31 RAS-RAF-MEK Pathway: Aberrations and Therapeutic Possibilities, 305
Javier Munoz and Filip Janku

32 The Phosphatidylinositol 3-Kinase Pathway in Human Malignancies, 315
Samuel J. Klempner,Thanh-Trang Vo, Andrea P. Myers, and Lewis C. Cantley

33 Current Status and Future Direction of PARP Inhibition in Cancer Therapy, 325
Saeed Rafii, Stan Kaye and Susana Banerjee

34 Targeting the c-Met Kinase, 341
Chad Tang, M. Angelica Cortez, David Hong, and James W. Welsh

35 KIT Kinase, 347
Scott E. Woodman

36 TP53, 353
Kensuke Kojima and Michael Andreeff

Part V Future Perspectives

37 Future Perspectives, 363
Rabih Said and Apostolia-Maria Tsimberidou

Index, 371