Immunopharmacology (eBook)

Front Cover 1
Immunopharmacology 4
Copyright Page 5
Table of Contents 6
LISTOF AUTHORS 8
PREFACE 10
PART I: IMMUNOGLOBULINS AND MECHANISMS 12
CHAPTER 1. 
14 
I.ANAPHYLACTIC ANTIBODIES OF THE GUINEA PIG AND MOUSE, .1 ITMMUNOGLOBULINS 15
II. ANAPHYLACTIC ANTIBODIES OF THE RAT, THE RABBIT AND THE DOG, "REAGENIC TYPE" 17
III. COMPARISION OF THE PROPERTIES OF THE .1 ANAPHYLACTIC ANTIBODT OF THE GUINEA PIG AND MOUSE RBBIT, DOG AND MAN 20
REFERENCES 22
DISCUSSION 23
CHAPTER 2. 
26 
REFERENCES 31
DISCUSSION 32
CHAPTER 3. 
34 
INTRODUCTION 34
I. IMMUNOCHEMICAL PROPERTIES OF SOLUBLE ANTIGEN-ANTIBODY COMPLEXES HAVING BIOLOGICAL REACTIVITY 35
II. BIOLOGICAL ACTIVITIES OF AGGREGATED y-GLOBULINS 39
III. MOLECULAR BASIS OF HYPERSENSITIVITY REACTIONS AND COMPLEMENT FIXATION 41
SUMMARY 43
REFERENCES 44
CHAPTER 4. 
46 
INTRODUCTION 46
METHODS AND MATERIALS 47
RESULTS 49
DISCUSSION 53
SUMMARY 53
ACKNOWLEDGMENT 54
REFERENCES 54
CHAPTER 5. 
56 
BIOCHEMICAL MECHANISM OF HISTAMINE RELEASE 57
BIOCHEMICAL FEATURES OF THE HISTAMINE-RELEASE MECHANISM 59
CELL MORPHOLOGY AND HISTAMINE RELEASE 71
REFERENCES 72
DISCUSSION 73
PAR II: MEDIATORS 76
CHAPTER 6. 
78 
HISTAMINE 79
HYDROXYTRYPTAMINE 79
BRADYKININ 80
SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS 80
LYMPH NODE PERMEABILITY FACTOR 83
INTERACTIONS OF FACTORS INFLUENCING VASCULAR PERMEABILITY 83
THE STUDY OF HUMAN ALLERGIC CONDITIONS 84
REFERENCES 85
DISCUSSION 86
CHAPTER 7. 
88 
ACKNOWLEDGMENTS 92
DISCUSSION 92
CHAPTER 8. 
94 
REFERENCES 99
CHAPTER 9. 
102 
DISCOVERY OF ARTHUS PERMEABILITY FACTOR 102
PURIFICATION OF ARTHUS PERMEABILITY FACTOR 104
BIOLOGIC PROPERTIES OF PURIFIED ARTHUS PERMEABILITY FACTOR 104
DISCUSSION AND SUMMARY 105
ACKNOWLEDGEMENTS 106
REFERENCES 106
CHAPTER 10. 
108 
A PERMEABILITY FACTOR IN LYMPH NODE CELLS 108
ACCUMULATION OF LNPF AT THE SITE OF A TUBERCULIN REACTION 110
HISTOLOGICAL EFFECTS OF LNPF 111
CHEMICAL PROPERTIES OF LNPF 112
ROLE OF LNPF IN OTHER DELAYED REACTIONS 113
MODE OF ACTION OF LNPF 114
HISTAMINE IN DELAYED HYPERSENSITIVITY 115
DELAYED HYPERSENSITIVITY AND RNA 116
CONCLUSIONS 117
REFERENCES 118
CHAPTER 11. 
120 
METHODES 120
RESULTATS 121
REFERENCES 125
DISCUSSION 125
CHAPTER 12. 
128 
MATERIALS AND METHODS 129
RESULTS 131
DISCUSSION 138
SUMMARY 141
ACKNOWLEDGMENTS 142
REFERENCES 142
DISCUSSION 142
CHAPTER 13. 
144 
A. THE RELATIONSHIP OF BOUND C'3 AND THE INFILTRATION OF POLYMORPHONUCLEAR LEUKOCYTES IN VIVO 145
B.STUDIES ON THE ROLE OF SERUM COMPLEMENT IN CHEMOTAXIS OF LEUKOCYTES IN VITRO 147
CONCLUSION 149
REFERENCES 149
PART III: DRUG ALLERGY 152
CHAPTER 14. 
154 
ABBREVIATIONS 154
I. INTRODUCTION 154
II.FORMATION OF THE COMPLETE ANTIGEN FROM THE DRUG 155
III. IMMUNOPATHOLOGICAL MECHANISMS OF DRUG ALLERGY 163
IV. CONSTITUTIONAL AND ENVIRONMENTAL FACTORS IN DRUG ALLERGY 168
V. CLINICAL APPLICATIONS 169
VI. CONCLUDING REMARKS 169
REFERENCES 170
INDEX 174