Essays in Toxicology (eBook)

Front Cover 1
Essays in Toxicology 4
Copyright Page 5
Table of Contents 10
List of Contributors 6
Preface 8
Chapter 1. Poisons as Tools in Studying the Nervous System 14
I. Introduction 15
II. Axonic Transmission 17
III. Excitatory Synaptic Transmission 23
IV. Inhibitory Synaptic Transmission 52
References 65
Chapter 2. Teratology 74
I. Introduction 74
II. Placental Physiology 77
III. Research Needs 80
IV. Nutritional Aspects 82
V. Genetic Factors 85
VI. Drugs 86
VII. Infectious Diseases 88
VIII. Mechanistic Causes 89
IX. Conclusion 89
References 90
Chapter 3. The Significance of Methemoglobinemia in Toxicology 96
I. Introduction 97
II. Therapeutic and Experimental Applications 97
III. Methemoglobinemia as a Toxic Reaction 106
IV. Pharmacology of Methylene Blue 111
V. Summary 122
References 122
Chapter 4. Lead Poisoning. An Old Problem with a New Dimension 128
I. Introduction 129
II. Historical Background 129
III. Industrial Lead Poisoning 130
IV. Lead Poisoning in Infants 131
V. Lead Poisoning in Domesticated Animals and Wildlife 131
VI. Sources and Uses of Lead 133
VII. Tetraethyl Lead and the General Environment 134
VIII. Perspectives Regarding Problem-Solving 137
IX. Current Knowledge Bearing on Existing Problems 138
X. The Metabolism of Lead 138
XI. Toxic Effects of Lead 149
XII. Lead as Related to the Incidence of Diseases 157
XIII. The Body Burden of Lead in the General Population 158
XIV. The Evaluation of Blood Levels 162
XV. The Role of Animal Experimentation 163
XVI. The New Dimension 163
References 164
AUTHOR INDEX 170
SUBJECT INDEX 178