Liver Disease in Children

Part 1 Pathophysiology of paediatric liver disease: structural and functional development of the liver; mechanisms and morphology of cholestasis; the cholangiopathies; fulminant hepatic failure in children; portal hypertension. Part 2 Evaluation of liver disease: laboratory assessment of liver function and injury in children; laboratory diagnosis of inborn errors of metabolism. Part 3 Cholestatic liver diseases: approach to the infant with cholestasis; medical and nutritional management of cholestasis; neonatal hepatitis and congenital infections; biliary atresia and other disorders of the extrahepatic bile ducts; neonatal jaundice and disorders of bilirubin metabolism, familial hepatocellular cholestasis; Alagille syndrome; diseases of the gallbladder in infancy, childhood, and adolescence. Part 4 Hepatitis and immune disorders: acute and chronic viral hepatitis; autoimmune hepatitis; sclerosing cholangitis; drug-induced liver disease; immune deficiency and the liver. Part 5 Metabolic liver disease: approach to child with metabolic liver disease; alpha1-antitrypsin deficiency; the liver and biliary tract in cystic fibrosis; inborn errors of carbohydrate metabolism; copper and iron storage disorders; neonatal haemochromatosis; porphyrins and porphyria; tyrosinemia; the lysosomal storage disorders; inborn errors of bile acid metabolism; inborn defects in mitochondrial fatty acid oxidation; mitochondrial hepatopathies; perioxisomal diseases; disorders of the urea cycle. Part 6 Other conditions and issues in paediatric hepatology: bacterial, parasitic, and fungal infections of the liver; systemic disease and the liver; fibrocystic liver disease; hepatic tumours in children; liver transplantation in children.