Sucralfate

Pathophysiology of Peptic Ulcer Disease.- Decreased Intragastric Acid Concentration as an Approach to Peptic Disease Therapy.- General Approach to Peptic Disease Therapy.- Ulcer Healing by Strengthening of Mucosal Defense.- History of the Development of Sucralfate.- Sucralfate: A Nonsystemic Site Protective Agent.- Chemistry of Sucralfate.- Binding of Bile Acids by Sucralfate.- Mechanisms of Action of Sucralfate.- Binding of Sucralfate to the Mucosal Surface.- Stimulation of Mucus Production.- Gastroduodenal Bicarbonate Secretion and its Response to Sucralfate.- Effect of Sucrose Octasulfate on Isolated Gastric Cells.- Effect on Gastric Surfactant.- Stimulation of Mucosal Prostaglandins by Sucralfate.- Sucralfate and Helicobacter pylori.- Sucralfate and Cell Proliferation.- Vascular Factors.- Sucralfate.- Effects of Sucralfate on Growth Factor Availability.- Duodenal Ulcer Therapy, “Acid Rebound,” and Early Relapse.- Effect of Sucralfate on Experimental Ulcers.- Effect on Experimental Esophageal Injury.- Safety and Drug Interactions.- Safety of Sucralfate.- Sucralfate Drug Interaction Studies.- Sucralfate and Therapy of Peptic Disease.- Therapy of Gastric Ulcer Disease.- Therapy of Active Duodenal Ulcers.- Prevention of Ulcer Recurrence.- Therapy of Esophagitis.- Sucralfate for NSAID-Induced Gastroduodenal Lesions.- The Preventive Use of Sucralfate.- Sucralfate for Prevention of Acute Gastrointestinal Bleeding.- Prevention of Respiratory Tract Infections with Sucralfate in Ventilated ICU Patients.- Sucralfate in Nonulcer Dyspepsia, Gastritis, and Duodenitis.- Use of Sucralfate in Variceal Sclerotherapy-Induced Ulcerations.- The Clinical Role of Sucralfate in Peptic Ulcer Therapy—Comparison with H-2 Blockers and Pump Inhibitors: A Projection for the Nineties.-Future Research into the Mechanisms of Action of Sucralfate.- Future Clinical Development of Sucralfate.