Buprenorphine Therapy of Opiate Addiction

1 Pharmacology of High-Dose Buprenorphine.- 1. Introduction.- 2. Pharmacokinetic Properties.- 3. Pharmacodynamic Properties.- 4. Administration Schedules.- 5. Clinical Effects of Buprenorphine.- 6. Conclusion.- References.- 2 Controlled Drug Administration Studies of High-Dose Buprenorphine in Humans.- 1. Introduction.- 2. Bioavailability.- 3. Dose-Effect Profiles.- 4. Abuse Liability.- 5. Toxicity.- 6. Safety and Abuse Liability of High-Dose Intravenous Buprenorphine.- 7. Conclusion.- References.- 3 High-Dose Buprenorphine for Treatment of Opioid Dependence.- 1. Introduction.- 2. Buprenorphine Solution vs Tablets.- 3. Efficacy of Buprenorphine vs Placebo: Clinical Trials.- 4. Efficacy of Buprenorphine vs Other Medications: Clinical Trials.- 5. Safety and Side Effects of Buprenorphine.- 6. Summary and Conclusions.- Acknowledgment.- References.- 4 Foreseeable Advantages and Limits of Buprenorphine-Naloxone Association.- 1. Introduction.- 2. Advantages of Buprenorphine-Naloxone Association.- 2.1.1. Epidemic of Pentazocine and Tripelennamine Abuse in the United States.- 2.1.2. Epidemic of Analgesic Buprenorphine Abuse in New Zealand.- 3. Limits of Buprenorphine-Naloxone Association.- 4. Conclusion.- References.- 5 Buprenorphine Maintenance Treatment in Primary Care: An Overview of the French Experience and Insight Into the Prison Setting.- 1. Introduction.- 2. Implementation of BMT Through French Primary Care System.- 3. Observable Effects of French Policy.- 4. Prison.- 5. Conclusion.- Acknowledgments.- References.- 6 Buprenorphine as a Viable Pharmacotherapy in Australia.- 1. Introduction.- 2. Buprenorphine.- 3. National Evaluation of Pharmacotherapies for Opioid Dependence.- 4. Conclusion.- Acknowledgments.- References.- 7 Separative Techniques for Determination of Buprenorphine.- 1. Introduction.- 2. Determination of Buprenorphine in Blood.- 3. Determination of Buprenorphine in Urine.- 4. Determination of Buprenorphine in Biological Tissues.- 5. Determination of Buprenorphine in Hair.- 6. Conclusion.- References.- 8 Buprenorphine-Related Deaths.- 1. Introduction.- 2. Forensic Aspects.- 3. Buprenorphine Fatalities.- 4. Conclusion.- References.- 9 Pharmacology of Opiates During Pregnancy and in Neonates.- 1. Introduction.- 2. Perinatal Pharmacokinetics of Opiates.- 3. Perinatal Pharmacodynamics of Opiates.- 4. Maintenance Treatments During Pregnancy.- References.- 10 Case Study of Neonates Born to Mothers Undergoing Buprenorphine Maintenance Treatment.- 1. Introduction.- 2. Clinical Findings.- 3. Toxicological Investigations.- 4. Discussion.- 5. Conclusion.- Acknowledgments.- References.- 11 Buprenorphine and Pregnancy: A Comparative, Multicenter Clinical Study of High-Dose Buprenorphine vs Methadone Maintenance.- 1. Introduction.- 2. Materials and Methods.- 3. Results.- 4. Discussion.- 5. Conclusion.- Acknowledgments.- References.