Shock Pathogenesis and Therapy

Definition and classification of various forms of shock.- Comparison of various forms of experimental shock.- Possible role of endotoxin in the perpetuation of shock.- Hemodynamic factors in shock.- Nervous adjustments of the vascular bed with special reference to patterns of vasoconstrictor fibre discharge.- Metabolic aspects of shock.- Microscopic observations of the mesenteric circulation in rabbits subjected to reversible and irreversible haemorrhagic shock.- The nature of irreversible shock: its relationship to intestinal changes.- Renal failure in shock.- Renal blood flow and renal clearances during hemorrhage and hemorrhagic shock.- The participation of the adrenal glands in endotoxin shock.- Aldosterone and alterations in circulatory reactivity following endotoxin.- Reflex mechanisms and the central nervous system.- The effects of emotional stress on the circulation through voluntary muscles.- Hemorrhagic and post-hemorrhagic shock.- The effect of hypovolaemic (stagnant) and arterial hypoxia on the distribution of cardiac output in dogs and rats.- Observations on haemo-respiratory effects of acute haemorrhage.- Clinical aspects of traumatic shock.- Pathogenesis and therapy of shock due to infection: experimental and clinical studies.- Toxic factors in shock (with special reference to burns).- On the pathogenetic therapy of shock.- Myocardial shock.- Allergic shock.- Radiation shock.- Shock and extracorporeal circulation.- Humoral and myogenic factors in shock: evaluated by means of isolated arteriolar smooth muscle response.- Hypothermia in shock.- Fluid substitution in shock.- Further aspects of fluid substitution.- Drug therapy of shock.- Some aspects of treatment in shock.- Closing remarks.- List of authors.