Perspectives in Inflammation

Section I Immunological Aspects of Inflammation.- 1. The rationale of using levamisole in the treatment of rheumatoid arthritis.- 2. Immunostimulation, levamisole and rheumatoid arthritis.- 3. The effect of cytotoxic drugs on the formation of mononuclear phagocytes.- 4. Rheumatoid factor–immunoglobulin G complex precipitation and neutrophil stimulation: an in vitro model for rheumatoid inflammation.- Chairman’s Summing-up and Future Trends—Immunological aspects of inflammation—the network of interactions.- General Discussion.- Perspectives in Inflammation.- Section II Chronic Inflammation: Cellular Events.- 5. A model for assessing effects of drugs on giranulocyte emigration in vivo.- 6. A polymorph abnormality in Crohn’s disease.- 7. The origin and kinetics of liver macrophages during steady state and inflammation (Abstract).- 8. Lymphocyte-mediated eosinophilia in guinea pigs with delayed hypersensitivity to a chemical.- 9. A role for L-lymphocytes in chronic inflammation.- 10. Cartilage degradation by macrophages, fibroblasts and synovial cells in culture. An in vitro model suitable for studies on rheumatoid arthritis.- 11. Adjuvant arthritis: immune responses and effects of Tilorone or interferon in partially suppressing the disease.- General Discussion.- Chairman’s Summing-up and Future Trends—Cellular reactions in inflammation.- Section III Chronic Inflammation: Mechanisms.- 12. The effect of local elevation of leukocyte cyclic AMP content on lysosomal enzyme release during acute inflammation in vivo.- 13. Recent studies on the secretory activity of mononuclear phagocytes with special reference to prostaglandins.- 14. Interactions of macrophages and complement components in the pathogenesis of chronic inflammation.- 15. Matrix vesicles and apatitenodules in arthritic cartilage.- 16. Crystal induced inflammation and osteoarthritis.- 17. Microanalysis of particulate material involved in inflammation.- 18. The influence of chemical composition of plasma membranes on the functional activities of macrophages.- Opening to Discussion—Mechanisms in chronic inflammation.- General Discussion.- Chairman’s Summing-up and Future Trends.- Section IV General Aspects I.- 19. Dual function of E-type prostaglandins in models of chronic inflammation.- 20. Interactions between prostaglandin E and cyclic nucleotides in chronic inflammatory disease.- 21. The time course of the vascular events associated with inflammation due to ultraviolet irradiation of guinea pig ears.- Perspectives in Inflammation.- 22. Role of macrophages in D-penicillamine-induced stimulation of DNA synthesis in lymph node cells in vitro.- 23. Anti-inflammatory effects of tumour bearing.- 24. Role of platelets and of prostaglandin synthetase on hypotensive effects of arachidonic acid and of carrageenan.- 25. Evidence for a pivotal role of the endoperoxide, PGG2, in inflammatory processes.- 26. Thiols and prostaglandin biosynthesis.- 27. Interactions of non-steroidal anti-inflammatory drugs with substance P-like and gastrointestinal hormones-like polypeptides.- 28. Salicylic acid and proquazone: the differences in absorption and biodistribution explain their different profile of side-effects.- 29. Degradation of bovine nasal cartilage by a neutral protease from human leukocyte granules.- 30. Inhibition of experimental ocular inflammation by topical application of non-steroidal anti-inflammatory drugs (NSAID).- 31. Potentiation of acenocoumarin-induced anticoagulation by a new anti-inflammatory agent in man (Abstract).- 32. In vitro methods for assessinganti-inflammatory drug activity (Abstract).- Section V General Aspects II.- 33. Potentiation of antibody formation by proteases in vitro.- 34. Triggers of prostaglandin release from macrophages.- 35. Biological, chemical and pharmacological induction of the properdin-mediated pathway of complement activation in vitro.- 36. Immune reactions of lymphocytes eluted from rheumatoid inflammatory tissue.- 37. Attempts at producing immune complexes in vitro between isolated macroglobulins and purified IgGs.- 38. Behaviour of some inflammation parameters in plasma and synovial fluid in some rheumatic diseases (Abstract).- 39. Some applications of quantitative two-dimensional immunoelectrophoresis in the study of the systemic acute-phase reaction of the rat.- 40. Restoration of the neutrophil chemotactic responsiveness by levamisole treatment in patients with recurrent infections, eczema and hyperimmunoglobulinaemia E.- 41. Rheumatoid-like joint lesions in rabbits injected intravenously with foreign serum.- 42. Anti-inflammatory activity of some bacterial immunostimulants. Relation with macrophage migration.- 43. Inflammatory exudates and mitogenic activity.- 44. Secretory activity of epithelioid cells.- 45. Vascular changes during acute inflammatory responses in rat hindpaws.- Perspectives in Inflammation.- Section VI Pharmacological Aspects: Animal/Man.- 46. Activators and inhibitors of fibrinolysis in rheumatoid joint inflammation.- 47. Relationships between increased vascular permeability, oedema, hyperalgesia and the effect of non-steroid anti-inflammatory drugs.- 48. Two sites of action of steroids on the prostaglandin system.- 49. Studies on the clinical and laboratory pharmacology of drug formulations of bovine Cu—Zn superoxide dismutases (orgotein).- 50. Humoralcontrol of monocytopoiesis (Abstract).- General Discussion.- Chairman’s Summing-up and Future Trends.- Section VII Pharmacological Aspects: Man/Animal.- 51. Difficulties in the clinical evaluation of new anti-inflammatory drugs.- 52. Is the mechanism of action during treatment of rheumatoid arthritis with penicillamine and gold thiomalate the same?.- 53. About immunological anomalies in treated and non-treated rheumatoid arthritis: rosette test and immunofluorescence of B-cells.- 54. Should penicillamine be prescribed for rheumatoid arthritis?.- 55. Long-term evaluation of intermittent levamisole treatment in rheumatoid arthritis.- General Discussion.- Closing Remarks.- Poster Sessions.