Autoimmunity and Toxicology

List of Contributors. Foreword (J.H. Dean and J.G. Vos). Preface (M.E. Kammuller, N. Bloksma and W. Seinen). SECTION I: INTRODUCTION Chapter 1: Autoimmunity and Toxicology. Immune disregulation induced by drugs and chemicals (M.E. Kammuller, N. Bloksma and W. Seinen). SECTION II: BASIC CONCEPTS Chapter 2: Basic mechanisms of adaptive immune system function (N. Bloksma and H.J. Schuurman). Chapter 3: Theories of self tolerance and autoimmunity (A.C. Allison). SECTION III: AUTOIMMUNE(-LIKE) REACTIONS IN HUMANS INDUCED BY DRUGS AND CHEMICALS Chapter 4: Autoimmune reactions induced by procainamide and hydralazine (R.L. Rubin). Chapter 5: Autoimmune reactions in humans induced by diphenylhydantoin and nitrofurantoin (D. Alarcon-Segovia and M. Alarcon-Riquelme). Chapter 6: Autoimmune reactions to D-penicillamine (P. Emery and G.S. Panayi). Chapter 7: Zimeldine: febrile reactions and peripheral neuropathy (A. Kristofferson and B.S. Nilsson). Chapter 8: Halothane hepatitis - an example of possible immune-mediated hepatotoxicity (J. Neuberger). SECTION IV: PROPERTIES OF IMMUNOMODULATING DRUGS AND CHEMICALS Chapter 9: Metabolism of procainamide, hydralazine, and isoniazid in relation to autoimmune(-like) reactions (D.W. Hein and W.W. Weber). Chapter 10: Drug interactions with complement components in relation to the induction of autoimmune(-like) reactions (E. Sim). Chapter 11: Immunomodulating properties of amphiphilic agents (L.A.Th. Hilgers, G.J.W.J. Zigterman and H. Snippe). SECTION V: EXPERIMENTAL APPROACHES TO ASSESS THE POTENTIAL OF CHEMICALS TO INDUCE AUTOIMMUNE(-LIKE) DISEASES Chapter 12: Propylthiouracil-induced immune-mediated disease syndrome in the cat: a novel animal model for a drug-induced lupus-like disease (D.P. Aucoin). Chapter 13: Autoimmune reactions induced by dietary antigens with an emphasis on amino acids (E.J. Bardana, Jr., A. Montanaro and M.R. Malinow). Chapter 14: Autoimmune(-like) reactions induced by metals (P. Druet et al.). Chapter 15: Testing the sensitization of T cells to chemicals. From murine graft-versus-host (GVH) reactions to chemical-induced GVH-like immunological diseases (E. Gleichmann et al.). Chapter 16: The pathology of diphenylhydantoin-induced lymphoproliferative reactions in animals (G.R.F. Krueger). Chapter 17: Immune-endocrine interactions and autoimmune diseases (S. Ansar Ahmed and N. Talal). Chapter 18: Toxicity of purine metabolites for human lymphoid cells: mechanisms and disease associations (B.J.M. Zegers, J.G.M. Scharenberg and G.T. Rijkers). Chapter 19: Toxicological considerations on immune disregulation induced by drugs and chemicals (M.E. Kammuller, N. Bloksma and W. Seinen). Subject index.