Antisense Oligodeoxynucleotides and Antisense RNANovel Pharmacological and Therapeutic Agents

This is a pharmacological and toxicological work on antisense, both oligodeoxynucleotides and RNA types. It discusses topics such as advances in the understanding of properties and antisense DNA therapy used on mice.

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The use of antisense strategies in modifying biological events signals a new era of pharmacotherapy. Antisense oligodeoxynucleotides and antisense RNA allow pharmacologists to design agents that are more predictable and selective in their actions. This book is a practical, state-of-the-art treatise on antisense oligodeoxynucleotide and antisense RNA technology and the potential application of these strategies in therapeutics. It describes both the advances and setbacks experienced in studying this revolutionary field of study. Critical analyses of the specificity of the agents are featured, and the possibility of antisense oligomers acting through non-antisense mechanisms is considered.

Antisense Oligodeoxynucleotides and Antisense RNA: Novel Pharmacological and Therapeutic Agents covers these important topics:
History of the early development of antisense oligodeoxynucleotides

How oligodeoxynucleotides have been chemically modified to increase their stability, delivery, and penetration into cells

Pharmacokinetic properties of antisense oligodeoxynucleotides

Non-antisense effects of antisense oligonucleotides

In vitro and in vivo model systems

Results of early clinical trials and the potential of agents for treating certain clinical disorders

The use of antisense oligodeoxynucleotides to study reproductive behavior, pain perception, hypertension, and cancer

The use of non-viral and viral expression vectors that encode antisense RNA sequences and their potential therapeutic applications in treating disorders involving abnormal cell growth, in inhibiting replication of HIV, and in treating a variety of neurobiological disorders