Antidotes for Poisoning by Cyanide

Preface; Abbreviations; Part I. Overview: 1. Historical review; 2. Potential sources of cyanide; 3. Toxicity of cyanide in man; 4. Mechanism of toxicity; 5. Clinical features; 6. Laboratory findings; 7. Biological detoxification of cyanide; 8. Protective measures for occupational exposure; 9. Treatment; 10. Summary of treatment recommendations; 11. Summary of analytical aspects; 12. Proposed areas for research; 13. New developments in cyanide antidotes; 14. References; Part II. Oxygen: 15. Introduction; 16. Name and chemical formula of antidote; 17. Physico-chemical properties of molecular oxygen; 18. Synthesis; 19. Analytical methods; 20. Storage conditions; 21. General properties; 22. Animal studies; 23. Volunteer studies of pulmonary oxygen toxicity; 24. Clinical studies of oxygen toxicity; 25. Summary of evaluation; 26. Model information sheet; 27. References; Part III. Sodium Thiosulfate: 28. Introduction; 29. Name and chemical formula of antidote; 30. Physico-chemical properties; 31. Synthesis; 32. Analytical methods; 33. Shelf-life; 34. General properties; 35. Animal studies; 36. Volunteer studies; 37. Clinical studies; 38. Clinical studies - case reports; 39. Summary of evaluation; 40. Model information sheet; 41. References; Part IV. Hydroxocobalamine: 42. Introduction; 43. Name and chemical formula of antidote; 44. Physico-chemical properties; 45. Synthesis; 46. Analytical methods; 47. Shelf-life; 48. General properties; 49. Animal studies; 50. Volunteer studies; 51. Clinical studies; 52. Clinical studies - case reports; 53. Summary of evaluation; 54. Model information sheet; 55. References; Part V. Dicobalt Edetate: 56. Introduction; 57. Name and chemical formula; 58. Physico-chemical properties; 59. Synthesis; 60. Analytical methods; 61. Stability and shelf-life; 62. General properties; 63. Animal studies; 64. Volunteer studies; 65. Clinical trials; 66. Clinical studies - case reports; 67. Summary of evaluation; 68. Model information sheet; 69. References; Part VI. Amyl Nitrate: 70. Introduction; 71. Name and chemical formula; 72. Physico-chemical properties; 73. Synthesis; 74. Analytical methods; 75. Shelf-life; 76. General properties; 77. Animal studies; 78. Volunteer studies; 79. Clinical studies; 80. Clinical studies - case reports; 81. Summary of evaluation; 82. Model information sheet; 83. References; Part VII. Sodium Nitrite: 84. Introduction; 85. Name and chemical formula; 86. Physico-chemical properties; 87. Synthesis; 88. Analytical methods; 89. Shelf-life; 90. General properties; 91. Animal studies; 92. Volunteer studies; 93. Clinical studies; 94. Clinical studies - case reports; 95. Summary of evaluation; 96. Model information sheet; 97. References; Part VIII. 4-Dimethylaminophenol: 98. Introduction; 99. Name and chemical formula; 100. Physico-chemical properties; 101. Synthesis; 102. Analytical methods; 103. Shelf-life; 104. General properties; 105. Animal studies; 106. Volunteer studies; 107. Clinical studies; 108. Clinical studies - case reports; 109. Summary of evaluation; 110. Model information sheet; Part IX. Methylene Blue and Toluidine Blue: 111. Methylene blue; 112. Toluidine Blue; Part X. Analytical Methods for Cyanide Alone and in Combination with Cyanide Antidotes in Blood: 113. Qualitative methods; 114. Microdiffusion technique; 115. References.