Stem Cell Therapeutics for Cancer (eBook)

Khalid Shah, MS, PhD is an Associate Professor of Neurology and Radiology at Massachusetts General Hospital Harvard Medical School, where he also directs the Molecular Neurotherapy and Imaging Lab and the Stem Cell Imaging and Therapeutics Program. In addition to Dr. Shah's teaching and directorial activities, he is also a member of the editorial board for Nature Medicine, PNAS, Journal of Clinical Investigation, Stem Cells and Nature Neuroscience.

Contributors vii

Preface xi

Section 1 Introduction 1

1 Stem Cell Sources and Their Potential for Cancer Therapeutics
3

Khalid Shah

Section 2 Migration and Fate of Stem Cells 11

2 The Role of CXCR4 as a Mediator of Glioma-Tropic Neural
Precursor Cell Migration 13

Moneeb Ehtesham, Elliot Min, and Rebecca Kasl

3 Tumor Tropism of Mesenchymal Stem Cells 21

Paula Y. P. Lam and Ivy A.W. Ho

Section 3 Stem Cell Therapy in Brain Cancer 39

4 Stem Cell-Mediated Trail Therapy for Highly Aggressive Brain
Tumors 41

Khalid Shah

5 Stem Cell-Mediated Prodrug Gene Therapy of High-Grade Brain
Tumors 57

Cestmir Altaner

6 Role of Naïve Cord Blood Stem Cells in Glioma Therapy
73

Venkata Ramesh Dasari, Kiran Kumar Velpula, and Jasti S.
Rao

7 Stem Cell-Based Antiangiogenic Therapies for Brain Tumors
87

Navid Redjal and Khalid Shah

8 Treatment of Metastatic Neuroblastoma with Mesenchymal Stem
Cell-Based Oncolytic Virotherapy 103

Manuel Ramírez and Javier García-Castro

Section 4 Stem Cell Therapy in Other Cancer Types 111

9 Umbilical Cord Matrix Stem Cells for Cytotherapy of Breast
Cancer 113

Naomi Ohta, Atsushi Kawabata, Deepthi Uppalapati, Susumu
Ishiguro, Deryl Troyer, and Masaaki Tamura

10 Mesenchymal Stromal Cells as Effective Tumor
Antigen-Presenting Cells in Cancer Therapeutics 127

Raphaëlle Romieu-Mourez and Jacques Galipeau

11 Diagnostic and Therapeutic Mesenchymal Stem Cells for Breast
Cancer Treatment 145

Róisín Dwyer

12 Genetically Engineered Stem Cell Therapies Targeting
Gastrointestinal Malignancy 159

Emily Keung, Peter J. Nelson, and Claudius Conrad

13 Mesenchymal Stem Cells in Prostate Cancer: Clinical
Opportunities 171

Diptiman Chanda and Selvarangan Ponnazhagan

14 Primed Mesenchymal Stromal Cells for Cancer Therapy 187

Augusto Pessina, Arianna Bonomi, Eugenio Parati, Roberto
Pallini, and Giulio Alessandri

Section 5 Combinatorial Stem Cell Therapies 203

15 MicroRNA Adjuvants in Stem Cell-Based Cancer Therapy
205

Maarten C. J. Anderegg and Maarten F. Corsten

16 Stem Cell-Based Combination Therapies for Cancer: Systemic
Delivery of a PI3K/mTOR Inhibitor (PI-103) and Stem Cell-Mediated
Delivery of TRAIL in Brain Tumors 219

Tugba Bagci-Onder

17 The Efficacy of Clinically Approved Agents with Stem
Cell-Delivered Therapeutics for Cancer Therapy 235

Hiroaki Wakimoto and Khalid Shah

Section 6 Tracking Stem Cells and Stem Cell-Based
Therapeutics 245

18 Imaging Migration and Fate of Stem Cells in Experimental
Models of Cancer 247

Deepak Bhere and Khalid Shah

19 Multifunctional Molecules for Interrogating Stem Cell-Based
Therapeutics 257

Shawn Hingtgen

20 Tracking Cancer-Targeted MSC with PET Imaging 273

Véronique Roelants and Jean-Louis Vanoverschelde

Index 289

Color plate is located between pages 244 and 245.