Liver Transplantation – Clinical Assessment and Management

James Neuberger MD, Professor of Hepatology, Queen Elizabeth Hospital, Birmingham. Professor Neuberger is the Associate Medical Director at NHS Blood and Transplant, and Professor of Hepatology, Queen Elizabeth Hospital, Birmingham. He has worked in many aspects of liver disease and transplantation and been involved with UK Transplant (UKT) for over 10 years. He is also Editor-in-Chief of LWW's Transplantation, the journal of the Transplantation Society, and on the board of several liver and transplant journals. He?has 295 articles listed on PubMed. Dr James Ferguson MD, Consultant Hepatologist, Queen Elizabeth Hospital, Birmingham. Interests include: cardiovascular and renal dysfunction after liver transplantation and the complications of portal hypertension; portal hypertension, vascular disorders of the liver, alcoholic liver disease and adolescent transition. Dr Philip Newsome, Senior Lecturer in Hepatology and Clinical Director of the Birmingham University Stem Cell Centre, Birmingham, UK. Dr Newsome has had many major research papers in scientific journals published as well as reviews and book chapters in the fields of virology, cancer and tumour immunology.?He has received major grants from NIHR, Wellcome Trust, UKSCF, BBSRC and the Medical Research Council.?He is an enthusiastic communicator on the theme of translational stem cell work and non-alcoholic fatty liver disease and gives frequent talks to various groups at both the local and national level.

List of Contributors, ix Foreword, xii Preface, xiv Acknowledgements, xv About the Companion Website, xvi Abbreviations, xvii PART 1 When to Refer a Patient for Liver Transplantation 1 General Considerations, 3 S. Tamir Rashid and Alexander E. Gimson 2 Prognostic Models in Liver Transplantation, 18 James Neuberger PART 2 Selection, Assessment and Management on the List 3 Assessing the Potential Transplant Recipient, 29 Diarmaid D. Houlihan and Philip N. Newsome 4 Consent, 39 Christopher J.E. Watson 5 Management on the Waiting List, 47 Sumeet K. Asrani and Jayant A. Talwalkar 6 Specific Diseases, 60 Ian A. Rowe and David J. Mutimer 7 Specific Issues of Selection including Non-Compliance, Futility, Nutritional and Social Issues, 73 Ken Simpson PART 3 Transplantation for Acute Liver Failure 8 Assessment of the Patient with Acute Liver Failure, 85 Ashley Barnabas and John O Grady 9 Management of the Patient with Fulminant Hepatic Failure Awaiting Liver Transplantation, 93 James Neuberger PART 4 Donation and Allocation 10 Liver Donation, 103 Gabriel C. Oniscu 11 Liver Allocation, 116 Richard B. Freeman, Jr 12 Alternatives to Orthotopic Liver Replacement, 125 James Neuberger 13 Surgical Aspects of Liver Transplantation, 129 Thamara Perera and Simon Bramhall PART 5 Care of the Liver Transplant Recipient 14 Introduction to Outcomes and Follow-Up, 147 James Neuberger 15 The Immune System in Liver Transplantation: Rejection vs.Tolerance, 160 Palak J. Trivedi and Nick D. Jones 16 Immunosuppression in Liver Transplantation, 184 Aaron James Chan and John R. Lake 17 Microbiological Prophylaxis in Liver Transplantation, 197 Matthew J. Armstrong and Philip N. Newsome 18 Managing the Liver Transplant Recipient with Abnormal Liver Blood Tests, 208 Joanna A. Leithead and James Ferguson 19 Managing Rejection, 227 Palak J. Trivedi and James Neuberger 20 Management of Renal Function, 248 James Ferguson 21 Management of Post-Transplant Ascites, 256 Chris Corbett and Philip N. Newsome 22 Cytomegalovirus and the Liver Transplant Recipient, 261 James Ferguson 23 Immunisation and Liver Transplantation, 268 James Neuberger 24 Contraception and Pregnancy, 274 Carlo B. Ramirez, Cataldo Doria, Michael J. Moritz, John M. Davison and Vincent T. Armenti 25 Common Drug Interactions, 283 Amanda Smith 26 Management of Recurrent Disease, 290 Michael R. Lucey 27 Managing Cardiovascular Risk in the Liver Transplant Recipient, 299 Joanna K. Dowman and Philip N. Newsome 28 Bone Disease in Liver Transplantation, 309 John Ayuk 29 Malignancy after Liver Transplantation, 316 James Neuberger 30 Post-Transplant Lymphoproliferative Disorder, 325 Joseph F. Buell, Nathan J. Shores, Thomas G. Gross, Jeremy R. Chapman and Angela C. Webster Colour plate section facing p. 170 Index, 337