Advances in Enzyme Regulation

Part 1 Chemotherapy and resistance: studies on the mechanisms of the cytotoxic ation of the mitomycin antibiotics in hypoxic and oxygenated EMT6 cells, A. Sartorelli et al; cellular resistance to alkylating agents, O.M. Colvin et al; effect of resistance on combination chemotherapy for human immunodeficiency virus infection, S.W. Cox et al. Part 2 Control of deoxycytidine kinase: regulation of deoxycytidine kinase activity, G. Weber et al; regulation of human deoxycytidine kinase expression and characterization of the gene, B.S. Mitchell et al. Part 3 Regulation of glocuse metabolism: mechanisms involved in the coordinate regulation of strategic enzymes of glucose metabolism, M.C. Sugden et al; fructose 2,6-bisphosphate and the control of glycolysis by growth factors, tumor promoters and oncogenes, L. Hue and G.G. Rousseau. Part 4 Enzymes as targets: drug resistance associated with altered DNA topoisomerase II, W.T. Beck et al; structural aspects of N-hydroxy-n'-aminoguanidine derivatives as inhibitors of L1210 cell growth and ribonucleotide reductase activity, J.G. Cory. Part 5 Mitogenic signalling and enzymology: early responses in mitogenic signalling; Bombesin induced protein phosphorylations in Swiss 3T3 cells, J. Van Lint et al; nuclear phosphoinositidase C during growth factor stimulation, L. Cocco et al. Part 6 Functions of protesomes and peroxisomes: regulation of protesome expression in developing and transformed cells, A. Ichihara et al; peroxisomal leukotriene degradation - biochemical and clinical implications, G. Jedlitschky et al. Part 7 Reaction mechanisms and enzymic properties: chemical modification of an arginine residue in aldose reductase is enhanced by coenzyme binding - further evidence for conformational change during the reaction mechanism, T.G. Flynn and T.J. Kubiseski; the properties and function of gamma-glutamyl hydrolase and poly-gamma-glutamate, Y. Wang et al. Part 8 Control of adenine nucleotides and nucleoside transport: the control of cellular adenine nucleotides - the discovery and metabolism of an oligomeric derivative of ATP and phosphoglyceric acid in mitochondrial intermembrane space, J. Mowbray and B. Patel; nucleoside transport in normal and neoplastic cells, J.A. Belt et al. Part 9 Molecular cloning, suppression of RAS and malignancy. Part 10 Special symposium lecture.