Drugs and the Liver: High Risk Patients and Transplantation

1. Risk Assessment in liver transplantation focus on lung function.- 2. Biochemical basis of hepatic ischemic/reperfusion injury.- 3. Donor rating and assessment of pretransplant prognosis by use of the MEGX test.- 4. Significance of cyclosporine pharmacokinetics in liver transplantation.- 5. Cyclosporin toxicity and liver transplantation in high risk patients.- 6. Drug treatment in liver transplanted patients: antihypertensive therapy.- 7. Bacteremia after liver transplantation; few issues in selection of antibiotics for treatment and prophylaxis.- 8. Antiviral drugs.- 9. The use of antiviral drugs in liver transplant patients.- 10. Drugs, fetal liver and reproduction.- 11. Reproduction after transplantation.- 12. Reproduction after liver transplantation for B-virus hepatitis.- 13. 24 hour-hypothermic preservation of rat liver with euro-collins and UW solutions. Comparative evaluation by 31P NMR spectroscopy, biochemical assays and light microscopy.- 14. ATP content during the ischemic period as an indicator of liver viability. A phosphorus-31 NMR study.- 15. Drugs and liver disease.- 16. Liver disease and anticancer drug treatment.- 17. Pharmacokinetics of anticancer agents in patients with impaired liver function.- 18. Pathogenesis and treatment of alcoholic liver disease.- 19. Liver fibrogenesis in chronic viral and alcoholic liver disease.- 20. Hepatocellular carcinoma.- 21. Treatment of iron dependent chronic liver disease.- 22. Liver transplantation for chronic liver disease.- 23. Practical uses of OKT3.- 24. Histopatology of acute liver rejection (ALR) in OKT3 treated patients.- 25. Spin-spin relaxation times as viability parameter of liver transplantation grafts. Investigation on a pig model.- 26. Urinary 6-? hydroxycortisol as a predictor of cyclosporineblood levels.- 27. Elucidation of the metabolic pathways of cyclosporine in vitro by human liver microsomes.- 28. Fine-needle aspiration biopsy and hepatotoxicity of cyclosporin a in orthotopic liver transplantation.- 29. Effect of FK 506 and cyclosporins on model membranes studied by nuclear magnetic resonance spectroscopy.