Colorectal Cancer

1 The Causes of Colorectal Cancer.- Descriptive Epidemiology and Temporal Trends.- The Environment and Colorectal Cancer.- Colorectal Polyps and the Adenoma-Carcinoma Sequence.- Familial and Hereditary Factors.- Gene-Environment Interactions.- Conclusions.- References.- 2 Pathogenesis of Colorectal Cancer.- Main Causes of Colorectal Cancer.- Pathogenesis of Colorectal Cancer: Different Molecular Pathways for One Disease.- Conclusions.- References.- 3 Pathology of Colorectal Cancer.- The Colorectal Mucosa.- Aberrant Crypts.- Adenomatous Polyps.- Other Types of Polyps.- Colorectal Carcinoma.- Conclusions.- References.- 4 Diagnosis and Clinical Features of Colorectal Cancer.- Clinical Findings: Symptoms and Signs.- Diagnosis of Colorectal Cancer: Old Methods and Recent Imaging Techniques.- Conclusions.- References.- 5 Colorectal Cancer Screening and Surveillance.- Colorectal Cancer Screening in the General Population.- New Screening Procedures Based on Molecular Analysis.- Screening in Individuals with Familial Colorectal Cancer.- Surveillance After Endoscopic Polypectomy.- Surveillance After Surgery for Colorectal Cancer.- Surveillance in Patients with Inflammatory Bowel Disease.- Surveillance in Hereditary Cancer Syndromes.- Conclusion: Media, Society and Colorectal Cancer Screening.- References.- 6 Prevention and Chemoprevention of Colorectal Neoplasms.- Can We Prevent Colorectal Cancer with an Appropriate Diet?.- Can We Prevent Colorectal Cancer by Modifying Our Lifestyle?.- Secondary Prevention: Is the Removal of Adenomas Effective?.- Colorectal Cancer Prevention Under Special Conditions.- Chemoprevention of Colorectal Cancer.- Conclusions.- References.- 7 Treatment of Colorectal Cancer.- Staging Colorectal Neoplasms.- Treatment of Resectable Colorectal Tumors.- Treatment of Advanced Colorectal Tumors.- Innovative Treatments for Colorectal Cancer.- Conclusions.- References.- 8 Survival and Follow-up of Colorectal Cancer.- Factors Influencing Colorectal Cancer Survival.- Temporal Trends and Ethnic Differences in Colorectal Cancer Survival.- Follow-up of Colorectal Cancer Patients.- Conclusions.- References.- 9 Cancer of the Anal Canal.- Epidemiology of Anal Cancer.- Clinical Features and Pathology.- Treatment of Cancer of the Anus.- Conclusions.- References.- 10 Hereditary Non-polyposis Colorectal Cancer (Lynch Syndrome).- Brief History of HNPCC.- Epidemiology and Frequency of Lynch Syndrome.- Formal Genetics and the Role of Family History.- Clinical Features of HNPCC.- Pathology of HNPCC.- Molecular Biology of HNPCC.- Diagnosis of HNPCC.- Genetic Counseling in HNPCC.- Management and Survival.- Conclusions.- References.- 11 Familial Adenomatous Polyposis.- Definition and Historical Overview.- Epidemiology and Formal Genetics.- Diagnosis, Clinical Features and Morphology.- Molecular Biology of FAP.- Management of Familial Adenomatous Polyposis.- Conclusions.- References.- 12 Other Polyposis of the Large Bowel.- Peutz-Jeghers Syndrome.- Juvenile Polyposis.- Cowden's Disease.- Turcot Syndrome.- Muir-Torre Syndrome and Other Rare Polyposis.- Bannayan-Riley-Ruvalcaba Syndrome.- Conclusions.- References.- 13 Carcinoid Tumors of the Large Bowel.- Brief History.- Biology and Pathology of CT.- Clinical Features of Colorectal CT.- Diagnosis and Treatment of CT of the Large Bowel.- Conclusions.- References.- 14 Colorectal Cancer at the Beginning of the New Millennium.- The Colorectal Cancer Epidemic.- Gene-Environment Interaction.- Dealing with Colorectal Cancer Patients in the "Molecular Era".- References.