Medicinal Chemistry of Nucleic Acids (eBook)

LI-HE ZHANG is President of the academic committee of State Key Laboratory of Natural and Biomimetic Drugs, as well as Professor of Medicinal Chemistry at Peking University. He is also a member of the Chinese Academy of Sciences, Fellow of the Royal Society of Chemistry, former vice president of the Chinese Pharmaceutical Association, and past president of the Asian Federation of Medicinal Chemistry. ZHEN XI, PhD, is Deputy Director of the State Key Laboratory of Elemento-organic Chemistry, as well as Professor of Pesticide Science and Chemical Biology, and Vice Dean of the College of Chemistry at Nankai University. He holds seven patents and has written a number of reviews and book chapters and sixty-four original research articles. JYOTI CHATTOPADHYAYA, PhD, DSc, is the University Chair of Bioorganic Chemistry and the chair of the Chemical Biology Program at Uppsala University. He is a guest professor of chemistry at both Jilin University and Nankai University. He has written over 410 peer-reviewed original research articles and is also on the editorial boards of several international journals.

FOREWORD vii

CONTRIBUTORS xi

INTRODUCTION xv

1 RECENT ADVANCES IN CARBOCYCLIC NUCLEOSIDES: SYNTHESIS AND
BIOLOGICAL ACTIVITY 1

Jianing Wang, Ravindra K. Rawal, and Chung K. Chu

2 STRUCTURES AND FUNCTIONS OF NUCLEIC ACIDS MODIFIED WITH S, Se,
AND Te AND COMPLEXED WITH SMALL MOLECULES 101

Wen Zhang, Jia Sheng, and Zhen Huang

3 UNRAVELING OF THE NAD CYCLIZING AND CALCIUM SIGNALING
FUNCTIONS OF HUMAN CD38 142

Hon Cheung Lee

4 DNA AND RNA BINDING SMALL MOLECULES 164

Shibo Li and Zhen Xi

5 G-QUADRUPLEX DNA AND ITS LIGANDS IN ANTICANCER THERAPY
206

Zhi-Shu Huang, Jia-Heng Tan, Tian-Miao Ou, Ding Li, and
Lian-Quan Gu

6 MOLECULAR MODELING IN NUCLEIC ACID-TARGETED DRUG DESIGN
258

Lidan Sun, Hongwei Jin, Liangren Zhang, and Lihe Zhang

7 STRUCTURE OF 10-23 DNAzyme IN COMPLEX WITH THE TARGET
RNA IN SILICO--A PROGRESS REPORT ON THE MECHANISM OF
RNA CLEAVAGE BY DNA ENZYME 272

Oleksandr Plashkevych and Jyoti Chattopadhyaya

8 LABELING OLIGONUCLEOTIDES TOWARD THE BIOMEDICAL PROBE
292

Il Joon Lee and Byeang Hyean Kim

9 LOCKED NUCLEIC ACID OLIGONUCLEOTIDES TOWARD CLINICAL
APPLICATIONS 335

Rakesh N. Veedu and Jesper Wengel

10 THE PHARMACOKINETICS RESEARCH OF NUCLEIC ACID DRUGS 349

Shengqi Wang, Dandan Lu, Qingqing Wang, Haifeng Song, Chan Gao,
Caihong Liu, and Ying Wang

11 INDUCIBLE RNAi AND DRUG TARGET VALIDATION 390

Wei Xiong, Jing Zhao, Yufan Zhang, Jinxi Wang, Yong-Xiang Zheng,
Qiu-Chen He, Li-He Zhang, and De-Min Zhou

12 siRNA: THE SPECIFICITY AND OFF-TARGET EFFECTS 405

Quan Du, Huang Huang, and Zicai Liang

INDEX 423

"The book gives a good overview on some aspects of current
research in the field. ... For those in the field seeking
inspiration, it is a good book." (ChemMedChem,
2012)