Evidence–Based Pediatric Oncology

Edited by Ross Pinkerton, MB, BCh, BaO, MD, Executive Director, Division of Oncology, Royal Children s Hospital, Children s Health Queensland, Brisbane, QLD, Australia Ananth Shankar, MD, FRCPCH, Consultant in Paediatric and Adolescent Oncology, University College London Hospitals NHS Foundation Trust, London, UK Katherine K. Matthay, BA, MD, Mildred V. Strouss Professor of Translational Oncology, Director, Pediatric Hematology-Oncology, Department of Pediatrics, UCSF School of Medicine and UCSF Benioff Children s Hospital, San Francisco, CA, USA

List of contributors, vii Preface, ix List of abbreviations, x About the companion website, xv Part 1: Solid tumors 1 Rhabdomyosarcoma, 3 Katherine K. Matthay (Commentary by Meriel Jenney) 2 Osteosarcoma, 14 Katherine K. Matthay (Commentary by Maria Michelagnoli) 3 Ewing sarcoma, 25 Katherine K. Matthay (Commentary by Steven G. DuBois) 4 Wilms tumor, 34 Ananth Shankar (Commentary by Kathy Pritchard-Jones) 5 Neuroblastoma, 47 Katherine K. Matthay (Commentary by Katherine K. Matthay) 6 Hepatoblastoma, 58 Ross Pinkerton (Commentary by Penelope Brock) 7 Malignant germ cell tumors, 65 Ross Pinkerton (Commentary by Ross Pinkerton) 8 Medulloblastoma, 69 Ross Pinkerton (Commentary by Eric Bouffet) 9 Glioma, 81 Ross Pinkerton (Commentary by Joann L. Ater) 10 Non-Hodgkin lymphoma, 88 Ross Pinkerton (Commentary by Ross Pinkerton) 11 Hodgkin lymphoma, 105 Ross Pinkerton (Commentary by Cindy L. Schwartz) Part 2: Leukemia Section 1: Acute myeloid leukemia 12 Acute myeloid leukemia commentary, 119 Robert J. Arceci 13 Remission induction in acute myeloid leukemia, 126 Ananth Shankar 14 Acute myeloid leukemia consolidation, 135 Ananth Shankar 15 Maintenance treatment in acute myeloid leukemia, 137 Ananth Shankar 16 Autologous bone marrow transplantation in acute myeloid leukemia, 141 Ananth Shankar 17 Acute myeloid leukemia: miscellaneous, 144 Ananth Shankar Section 2: Childhood lymphoblastic leukemia 18 Childhood lymphoblastic leukemia commentary, 146 Vaskar Saha 19 Remission induction in childhood lymphoblastic leukemia, 154 Ananth Shankar 20 Central nervous system-directed therapy in childhood lymphoblastic leukemia, 168 Ananth Shankar 21 Maintenance treatment in childhood lymphoblastic leukemia, 180 Ananth Shankar 22 Relapsed childhood lymphoblastic leukemia, 198 Ananth Shankar 23 Postinduction therapy in adolescents and young adults with acute lymphoblastic leukemia, 204 Ananth Shankar Part 3: Supportive care in pediatric oncology 24 Colony-stimulating factors, 209 Ananth Shankar (Commentary by Victoria Grandage) 25 Cardioprotection in pediatric oncology, 230 Ananth Shankar (Commentary by Gill A. Levitt) 26 Infections in pediatric and adolescent oncology, 243 Ananth Shankar and Sara Stoneham (Commentary by Julia E. Clark) Index, 269