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Polypharmacology in Drug Discovery (eBook)

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2012 | 1. Auflage
536 Seiten
John Wiley & Sons (Verlag)
978-1-118-09813-4 (ISBN)

Lese- und Medienproben

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An essential outline of the main facets of polypharmacology in
drug discovery research

Extending drug discovery opportunities beyond the "one drug, one
target" philosophy, a polypharmacological approach to the treatment
of complex diseases is emerging as a hot topic in both industry and
academic research. Polypharmacology in Drug Discovery presents an
overview of the various facets of polypharmacology and how it can
be applied as an innovative concept for developing medicines for
treating bacterial infections, epilepsy, cancer, psychiatric
disorders, and more. Filled with a collection of instructive case
studies that reinforce the material and illuminate the subject,
this practical guide:

* Covers the two-sided nature of polypharmacology--its
contribution to adverse drug reactions and its benefit in certain
therapeutic drug classes

* Addresses the important topic of polypharmacology in drug
discovery, a subject that has not been thoroughly covered outside
of scattered journal articles

* Overviews state-of-the-art approaches and developments to help
readers understand concepts and issues related to
polypharmacology

* Fosters interdisciplinary drug discovery research by embracing
computational, synthetic, in vitro and in vivo pharmacological and
clinical aspects of polypharmacology

A clear road map for helping readers successfully navigate
around the problems involved with promiscuous ligands and targets,
Polypharmacology in Drug Discovery provides real examples, in-depth
explanations and discussions, and detailed reviews and opinions to
spark inspiration for new drug discovery projects.

Jens-Uwe Peters, PhD, works in the Medicinal Chemistry Department at F. Hoffmann-La Roche. In his ten years at Roche, he has been involved in numerous drug discovery projects, has contributed to Early Safety Profiling initiatives, and has researched opportunities for polypharmacological drug discovery. Dr. Peters is author or coauthor on twenty-six journal papers and is named on twenty-two patents.

"The book is well presented and the price is reasonable
for anyone (drug designers, medicinal chemists, biochemists,
biologists, clinicians and toxicologists) interested in any of the
many facets that come together to make
polypharmacology." (British Toxicology Society,
1 July 2013)

"However, anyone interested in the complex issues relating
to drug promiscuity should find this very timely and topical book
to be a reliable and stimulating reference that they will revisit
many times." (ChemMedChem, 2012)

"Only recently, the characterization of promiscuous
ligands turned from 'dirty drugs' into 'agents
being rich in pharmacology.' ... Polypharmacology in
Drug Discovery covers all aspects, the good, the bad and the
ugly. On the one hand, a lack of specificity (the
'bad') causes more or less serious side effects;
inhibition of certain antitargets (the 'ugly'), e.g.
the hERG channel, results in a termination of a development
project, in the past even the withdrawal of already marketed drugs;
on the other hand, a desired promiscuity (the 'good')
may be beneficial, e.g. in the case of certain CNS drugs and of
anti-tumor kinase inhibitors. In Peters' book, all these
topics are discussed in great detail by internationally leading
authors. Therefore, Polypharmacology in Drug Discovery is of
utmost importance for all drug designers, medicinal chemists as
well as biochemists and biologists. The price of the book is in
excellent relationship to its 500 pages and the overall quality, in
content and presentation."--Prof. Dr. Hugo Kubinyi

Erscheint lt. Verlag	20.1.2012
Sprache	englisch
Themenwelt	Medizin / Pharmazie ► Gesundheitsfachberufe
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Naturwissenschaften ► Chemie
Schlagworte	Chemie • Chemistry • Computational Chemistry & Molecular Modeling • Computational Chemistry u. Molecular Modeling • Drug Discovery & Development • Medical Science • Medizin • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung
ISBN-10	1-118-09813-7 / 1118098137
ISBN-13	978-1-118-09813-4 / 9781118098134

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