Pharmacogenomics of Human Drug Transporters – Clinical Impacts

TOSHIHISA ISHIKAWA, PhD, is Senior Scientist at RIKEN Yokohama Institute and Professor of Biochemistry, Molecular Biology, and Pharmacogenomics at Yokohama City University's Graduate School of Medicine. Previously, Dr. Ishikawa was the Director of the Department of Research Technology Development at Pfizer, Japan. A recipient of the Achievement Award from the International Life Sciences Institute (ILSI), Dr. Ishikawa is also the cofounder of the International Transporter Consortium (ITC). RICHARD B. KIM, MD, FRCPC, is Professor and Chair of the Division of Clinical Pharmacology and Associate Chair for Research in the Department of Medicine at the University of Western Ontario. He is a Fellow of the American Association of Pharmaceutical Scientists and an elected member of the American Society for Clinical Investigation. JORG KONIG , PhD, is Professor and Head of the Molecular Biology Laboratories in the Department of Clinical Pharmacology at the Friedrich-Alexander Universitat Erlangen-Nurnberg.

PREFACE vii CONTRIBUTORS ix CHAPTER 1 INTRODUCTION TO PHARMACOGENOMICS OF DRUG TRANSPORTERS 1 Marianne K. DeGorter and Richard B. Kim CHAPTER 2 ADME PHARMACOGENOMICS IN DRUG DEVELOPMENT 13 Liangfu Chen and Joseph W. Polli CHAPTER 3 REGULATORY PERSPECTIVE ON PHARMACOGENOMICS OF DRUG-METABOLIZING ENZYMES AND TRANSPORTERS 39 Lei Zhang, Gilbert J. Burckart, Lawrence J. Lesko and Shiew-Mei Huang CHAPTER 4 THE PHARMACOGENOMICS OF MEMBRANE TRANSPORTERS PROJECT 73 Sook Wah Yee, Deanna L. Kroetz and Kathleen M. Giacomini CHAPTER 5 EMERGING NEW TECHNOLOGY OF SNP TYPING 109 Toshihisa Ishikawa and Yoshihide Hayashizaki CHAPTER 6 OATP1A2, OAT1, AND OAT3 125 Rommel G. Tirona CHAPTER 7 OATP1B1, OATP1B3, AND OATP2B1 141 J¨org K¨onig and Martin F. Fromm CHAPTER 8 OCT (SLC22A) AND OCTN FAMILY 171 Sophie L. Stocker, Arian Emami Riedmaier, Matthias Schwab and Kathleen M. Giacomini CHAPTER 9 MATE (SLC47) FAMILY 209 Atsushi Yonezawa and Ken-ichi Inui CHAPTER 10 PEPT (SLC15A) FAMILY 223 Tomoko Sugiura, Saki Umeda, Akira Tsuji and Yukio Kato CHAPTER 11 NUCLEOSIDE TRANSPORTERS (SLC28 AND SLC29) FAMILY 243 M'yriam Molina-Arcas and Marc¸al Pastor-Anglada CHAPTER 12 P-GLYCOPROTEIN (MDR1/ABCB1) 271 Ingolf Cascorbi CHAPTER 13 BSEP (ABCB11) 295 Bruno Stieger and Gerd A. Kullak-Ublick CHAPTER 14 BCRP (ABCG2) 311 Agnes Basseville, Susan E. Bates, William D. Figg and Alex Sparreboom CHAPTER 15 MRP2 (ABCC2) AND MRP3 (ABCC3) 345 Anne T. Nies CHAPTER 16 MRP4 (ABCC4) 365 Satish B. Cheepala, Mugdha Sukthankar and John D. Schuetz CHAPTER 17 MRP8 (ABCC11) 387 Yu Toyoda and Toshihisa Ishikawa CHAPTER 18 FUTURE PERSPECTIVES 401 Toshihisa Ishikawa and Joseph Ware INDEX 417