Practical Transfusion Medicine

List of contributors, ix

Preface to the Fourth Edition, xvi

1 Introduction: recent evolution of transfusion medicine, 1
Paul M. Ness

Part One: Basic Principles of Immunohaematology

2 Essential immunology for transfusion medicine, 11
Jaap Jan Zwaginga & S. Marieke van Ham

3 Human blood group systems, 21
Geoff Daniels

4 Human leucocyte antigens, 31
Cristina V. Navarrete

5 Platelet and neutrophil antigens, 45
David L. Allen, Geoffrey F. Lucas & Michael F. Murphy

Part Two: Complications of Transfusions

6 Investigation of acute transfusion reactions, 65
Kathryn E. Webert & Nancy M. Heddle

7 Haemolytic transfusion reactions, 77
Edwin J. Massey, Robertson D. Davenport & Richard M. Kaufman

8 Febrile and allergic transfusion reactions, 89
Mark K. Fung & Nancy M. Heddle

9 Acute lung injury after transfusion, 97
Steven H. Kleinman & Ram Kakaiya

10 Purported adverse effects of transfusion-related immunomodulation and of the transfusion of 'old blood', 106
Eleftherios C. Vamvakas

11 Transfusion-associated graft-versus-host disease and microchimerism, 116
Beth H. Shaz, Richard O. Francis & Christopher D. Hillyer

12 Posttransfusion purpura, 127
Michael F. Murphy

13 Transfusion-transmitted infections, 132
Roger Y. Dodd & Susan L. Stramer

14 Bacterial contamination, 144
Sandra Ram´?rez-Arcos & Mindy Goldman

15 Variant Creutzfeldt-Jakob disease, 152
Marc L. Turner

16 Emerging infections and transfusion safety, 161
Roger Y. Dodd

Part Three: Practice in Blood Centres and Hospitals

17 Regulatory aspects of blood transfusion, 171
William G. Murphy, Louis M. Katz & Peter Flanagan

18 The role of haemovigilance in transfusion safety, 181
James P. AuBuchon & Katharine A. Downes

19 Donors and blood collection, 190
Ellen McSweeney & William G. Murphy

20 Blood donation testing and the safety of the blood supply, 201
Richard Tedder, Simon J. Stanworth & Mindy Goldman

21 Production and storage of blood components, 209
Rebecca Cardigan & Stephen Thomas

22 Medicolegal aspects of transfusion practice, 224
Patricia E. Hewitt

23 Blood transfusion in hospitals, 230
Erica M. Wood, Mark H. Yazer & Michael F. Murphy

24 Blood transfusion in a global context, 250
David J. Roberts, Alan D. Kitchen, Stephen Field, Imelda Bates & Jean Pierre Allain

Part Four: Clinical Transfusion Practice

25 Inherited and acquired coagulation disorders, 263
Vickie McDonald & Samuel J. Machin

26 Massive blood loss, 276
Beverley J. Hunt & John R. Hess

27 Good blood management in acute haemorrhage and critical care, 284
Gavin J. Murphy, Nicola Curry, Nishith Patel & Timothy S. Walsh

28 Haematological disease, 300
Lise J. Estcourt, Simon J. Stanworth & Michael F. Murphy

29 Blood transfusion in the management of patients with haemoglobinopathies, 314
David C. Rees

30 Heparin-induced thrombocytopenia, 322
Andreas Greinacher & Theodore E. Warkentin

31 Immunodeficiency and immunoglobulin therapy, 335
Siraj A. Misbah

32 Fetal, neonatal and childhood transfusions, 347
Irene Roberts, Naomi Luban & Helen V. New


33 Recombinant proteins in diagnosis and therapy, 368
Marion Scott

Part Five: Alternatives to Transfusion

34 Principles of patient blood management, 379
Aryeh Shander & Lawrence Tim Goodnough

35 Autologous transfusion, 390
Dafydd Thomas, Biddy Ridler & John Thompson

36 Blood substitutes, 399
David J. Roberts & Chris V. Prowse

37 Pharmacological agents and recombinant activated factor VIIa, 410
Beverley J. Hunt & Simon J. Stanworth

Part Six: Cellular and Tissue Therapy and Organ Transplantation

38 Regulation and accreditation in cellular therapy, 421
Derwood H. Pamphilon & Zbigniew M. Szczepiorkowski

39 Stem cell collection and therapeutic apheresis, 433
Khaled El-Ghariani & Zbigniew M. Szczepiorkowski

40 Haemopoietic stem cell processing and storage, 443
Ronan Foley & Pamela O'Hoski

41 Haemopoietic stem cell transplantation, 455
I. Grant McQuaker & Ian M. Franklin

42 Cord blood transplantation, 464
Rachael Hough

43 Recent advances in clinical cellular immunotherapy, 473
Mark W. Lowdell & Emma Morris

44 Tissue banking, 480
Akila Chandrasekar, Paul Rooney & John Kearney

Part Seven: Development of the Evidence Base for Transfusion

45 Observational and interventional trials in transfusion medicine, 491
Alan Tinmouth, Dean Fergusson & Paul C. H´ebert

46 Getting the most out of the evidence for transfusion medicine, 505
Simon J. Stanworth, Susan J. Brunskill, Carolyn Doree, Sally Hopewell & Donald M. Arnold

47 Variation in transfusion practice and how to influence clinicians' use of blood in hospitals, 516
Simon J. Stanworth, J.J. Francis, Michael F. Murphy & Alan T. Tinmouth

48 Scanning the future of transfusion medicine, 524
Dana V. Devine, Walter H. Dzik & Zbigniew M. Szczepiorkowski

Index, 537

Colour plate section can be found facing page 432