Liver Carcinogenesis

Molecular pathways in hepatocyte proliferation.- HGF and liver growth regulation.- Structure, pleiotropic actions and organotrophic roles of hepatocyte growth factor.- Hepatocyte Growth Factor and its variant with a deletion of five amino-acids are distinguishable in biological, physicochemical and immunochemical properties.- Growth stimulation mediated by G protein-coupled receptors in hepatocytes: Synergism with epidermal growth factor and mechanisms of signal transduction.- Protein tyrosine phosphatases in signal transduction.- C-myc is essential for initiation of DNA synthesis in EGF-stimulated hepatocyte cultures.- Cellular biology of the rat hepatic stem cell compartment.- Changes in protein expression during oval cell proliferation in the liver.- Stem cell activation in the acetylaminofluorene-treated regenerating rat liver: A bile ductular reaction?.- Apoptosis and its role in hepatic carcinogenesis by non-genotoxic agents.- Cell proliferation and cell death in the liver: Patterns, mechanisms and measurements.- Preneoplastic changes during non-genotoxic hepatocarcinogenesis.- mRNA composition of rat liver tumors initiated by aromatic amines.- Liver ?-Glutamyl transpeptidase activity after cyclosporine A and amlodipine treatment.- Enhanced expression of the 27KDa heat-shock protein during DENA-induced hepatocarcinogenesis in rat and in human neoplastic and non-neoplastic liver tissues.- Hepatic recovery of dimethylnitrosamine-cirrhotic rats after injection of the liver growth factor.- Cell contact-mediated regulation of hepatocyte differentiation/proliferation: Role of LRP(s).- Interactions of human hepatocytes with hepatitis B virus.- Liver-specific aspects of hepatitis B virus gene expression.- Transcriptional involvement of the hepatitis B virus protein incellular transduction systems. Protein-protein interactions with bZip transactivators.- Role of duck hepatitis B virus infection, aflatoxin B1 and p53 mutation in hepatocellular carcinomas of ducks.- The preparation and culturing of rat hepatocytes.- Isolation and growth of hepatocytes and biliary epithelial cells from normal and diseased human livers.- A novel strategy for isolating HEPR, a human small intestinal cytidine deaminase.- Regenerating liver: Isolation of up- and down-regulated gene products.- Hepatotrophic and renotrophic activities of HGF in vivo: Possible application of HGF for hepatic and renal diseases.- Targeted gene delivery and expression.- Studies on persistence and enhancement of targeted gene expression.- The generation of tumor vaccines by adenovirus-enhanced transferrinfection of cytokine genes into tumor cells.