Rheumatoid Arthritis

Recent Research Advances

Josef S. Smolen, Joachim R. Kalden, Ravinder N. Maini (Herausgeber)

Buch | Softcover

XX, 399 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1992
Springer Berlin (Verlag)
978-3-642-76191-1 (ISBN)

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Many advances have occurred in the last 5 years especiallyin understanding genetic susceptibility factors, the role ofimmune response in chronic arthritis and the relationshipbetween cellular processes that underlie inflammation andtissue damage. All these are dealt with in depth in theindividual contributions.Genetics studies included illustrate how studies of HLAgenes and genes controlling the autoantibody repertoire maybe involved. Environmental factors are believed to beimportant and studies both in humans and in experimentalmodels on the role of viral and bacterial agents arecovered. The fascinating relationship between microbes,dysregulated immune responses and oncogenes are alsoexamined.Since autoimmunity is the key aspect of the immunologicalresponse in rheumatoid arthritis, the role of antigens isre-examined as is the part played by immune T and B cells.New areas of clinical application of basic science is wellpresented in this book, forexample, in examining howmarkers of cartilage destruction may become important inmonitoring disease activity. A chapter reviewing possiblefuture novel therapies is included.

Is Rheumatoid Arthritis a Disappearing Disease?.- Genetics.- Genetic Factors in Rheumatoid Arthritis.- Rheumatoid Arthritis in Southeastern Europe.- Pathogenesis.- Pathogenesis of Rheumatoid Arthritis: Cellular and Cytokine Interactions.- Role of Cellular Adhesion in Rheumatoid Synovitis.- Endothelial Cells and Dendritic Cells in Rheumatoid Inflammation.- Cellular and Humoral Immune Response Against Articular Chondrocytes and Proteoglycans in Rheumatoid Arthritis.- Role and Regulation of Synovial MHC Class II Antigens in Rheumatoid Arthritis and Related Diseases.- CD5+ B Cells and Double-Negative T Cells in Rheumatoid Arthritis.- The Genetics of Rheumatoid Factors (RF): The V-gene Repertoire of RFs in Rheumatoid Arthritis as Analyzed by Hybridoma Clones.- Neutrophil Polymorphonuclear Cell Function in Rheumatoid Arthritis.- Etiologic Factors - Bacterial Antigens, Autoantigens, Viruses.- Heat-Shock Proteins and Mycobacterial Antigens.- Type-II Collagen in the Pathogenesis of Rheumatoid Arthritis.- Streptococcal Cell Wall Antigens and Rheumatoid Arthritis.- Caprine Arthritis-Encephalitis.- Oncogenes and Retroviruses in Rheumatoid Arthritis.- Are Retroviruses Involved in the Pathogenesis of Autoimmune Diseases?.- Epstein-Barr Virus and Rheumatoid Arthritis.- Antibodies to EBV-Encoded Proteins in Rheumatoid Arthritis.- Autoantibodies and Markers of Disease Activity.- The Antiperinuclear Factor (APF) and Antikeratin Antibodies (AKA) in Rheumatoid Arthritis.- Anti-RA33: A New Antinuclear Antibody in Rheumatoid Arthritis.- Acute-Phase Response and Amyloid.- Markers of Cartilage Destruction.- Therapy.- Progress in the Therapy of Rheumatoid Arthritis.- T-Cell Vaccination - A Prospect.

Erscheint lt. Verlag	21.12.2011
Zusatzinfo	XX, 399 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	638 g
Themenwelt	Medizinische Fachgebiete ► Chirurgie ► Unfallchirurgie / Orthopädie
	Medizinische Fachgebiete ► Innere Medizin ► Rheumatologie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Schlagworte	Antibody • Antigen • Arthritis • autoimmunity • Autoimmunkrankheit • Bacteria • Cartilage • Entzündung • Genetics • immune response • Immungenetik • immunity • immunogenetics • Infection • Infektion • inflammation • Joint • Rheumatism • Rheumatoid Arthritis • Rheumatoide Arthritis (Gelenkrheumatismus) • Therapie • therapy
ISBN-10	3-642-76191-7 / 3642761917
ISBN-13	978-3-642-76191-1 / 9783642761911
Zustand	Neuware