Alcohol Metabolism, Alcohol Intolerance, and Alcoholism

1 Introduction.- 2 Alcohol Metabolism: Biochemistry and Genetic Variations.- 2.1Absorption, Body Distribution, and Elimination of Ethanol.- 2.2 Biochemical Pathways of Ethanol Degradation.- 3 Alcohol-Metabolizing Enzymes and Acute Reactions to Alcohol.- 3.1Ethanol- and Acetaldehyde-Mediated Acute Response to Alcohol.- 3.2 Ethnic Differences in Acute Response to Alcohol 53.- 3.3 Mechanism of Alcohol Sensitivity.- 3.4 Racial-Ethnic Patterns of Alcohol Abuse and Alcoholism.- 4Biochemical Aspects of Alcoholism.- 4.1 Alcohol-Related Metabolic Derangements.- 4.2 Metabolic Changes.- 4.3Changes in Alcohol-Metabolizing Enzymes in Alcohol-Related Disorders.- 4.4Biochemical Markers of Alcohol Abuse and Alcoholism.- 5Neuropsychopharmacology of Alcoholism.- 5.1 Alcohol Effects in the CNS.- 5.2Addiction, Tolerance, and Dependence.- 5.3Metabolic Factors.- 6Genetic Factors in Alcoholism.- 6.1 Ethnic and Cultural Variables.- 6.2 Familial and Nonfamilial Alcoholism.- 6.3 Genetic Contributions.- 6.4Genetic and Environmental Interactions in Alcoholism.- 6.5Biological Mediators of Alcoholism.- 7Experimental Section.- 7.1Subjects and Materials.- 7.2Methods.- References 145.- Subject Index 179.