Biology of the Pancreatic Cell (eBook)
354 Seiten
Elsevier Science (Verlag)
978-0-08-087714-3 (ISBN)
1. the inherent scientific interest in understanding secretion of the pancreatic ß,-cell
2. the ß,-cells relevance to a very common disease
3. the availability of funding from specific sources related to diabetes research, for instance, Juvenile Diabetes Foundation International and the British Diabetic Association.
As a result of all this activity, detailed scientific literature including research reviews are readily available.
Surprisingly enough, there are relatively few attempts to summarize this great bulk of knowledge in a way that is accessible to the newcomer to this field and this book is intended to bridge this gap.
As a result of the key advances made more than 30 years ago, specifically the ability to isolate islets of Langerhans from the pancreas, the ability to measure insulin accurately by immunoasay, and the development of microchemical techniques for studying cells and their components, many research volumes, symposium reports, and original papers have been produced. This explosion of interest has probably had at least three stimuli: 1. the inherent scientific interest in understanding secretion of the pancreatic -cell2. the -cells relevance to a very common disease3. the availability of funding from specific sources related to diabetes research, for instance, Juvenile Diabetes Foundation International and the British Diabetic Association. As a result of all this activity, detailed scientific literature including research reviews are readily available. Surprisingly enough, there are relatively few attempts to summarize this great bulk of knowledge in a way that is accessible to the newcomer to this field and this book is intended to bridge this gap.
Front Cover 1
Advances in Molecular and Cell Biology: The Biology of the Pancreatic ß-cell 4
Copyright Page 5
CONTENTS 6
LIST OF CONTRIBUTORS 8
PREFACE 12
SECTION I: ß-CELL DEVELOPMENT, REPLICATION, AND DEATH 14
CHAPTER 1. DEVELOPMENTAL BIOLOGY OF THE ß-CELL 16
CHAPTER 2. PANCREATIC ß-CELL LINES: THEIR ROLES IN ß-CELL RESEARCH AND DIABETES THERAPY 34
CHAPTER 3. ß-CELL DYSFUNCTION AND DEATH 60
CHAPTER 4. ISLET PROTEINS IMPLICATED IN PATHOGENESIS OF TYPE 1 DIABETES MELLITUS 88
SECTION II: CELLULAR MECHANISMS OF INSULIN SYNTHESIS AND SECRETION 114
CHAPTER 5. INSULIN GENE EXPRESSION 116
CHAPTER 6. PROINSULIN PROCESSING AND INSULIN STORAGE 138
CHAPTER 7. MECHANISM OF INSULIN EXOCYTOSIS 164
SECTION III: REGULATION OF INSULIN SECRETION 186
CHAPTER 8. POTENTIATORS AND INHIBITORS OF INSULIN SECRETION 188
CHAPTER 9. SIGNAL RECOGNITION: GLUCOSE AND PRIMARY STIMULI 212
CHAPTER 10. ION CHANNEL SIGNAL TRANSDUCTION IN PANCREATIC ß-CELLS 240
CHAPTER 11. SIGNAL TRANSDUCTION: REGULATION OF INSULIN SECRETION BY CHANGES IN Ca2+ CONCENTRATION AND ACTION IN PANCREATIC ß-CELLS 260
CHAPTER 12. ROLES OF PHOSPHOLIPIDS AND PHOSPHOLIPASE ACTIVATION IN ß-CELL FUNCTION 290
CHAPTER 13. SIGNAL TRANSDUCTlON: PROTEIN PHOSPHORYLATION AND THE REGULATION OF INSULIN SECRETION 316
SECTION IV: CONCLUSION 348
CHAPTER 14. FUTURE CHALLENGES IN ß-CELL RESEARCH 350
INDEX 360
Erscheint lt. Verlag | 15.4.1999 |
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Sprache | englisch |
Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie |
Medizinische Fachgebiete ► Innere Medizin ► Gastroenterologie | |
Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie | |
Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
Naturwissenschaften ► Biologie ► Zellbiologie | |
Technik | |
ISBN-10 | 0-08-087714-1 / 0080877141 |
ISBN-13 | 978-0-08-087714-3 / 9780080877143 |
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