Natural Products (eBook)

Drug Discovery and Therapeutic Medicine

Lixin Zhang, Arnold L. Demain (Herausgeber)

eBook Download: PDF
2007 | 2005
XIV, 386 Seiten
Humana Press (Verlag)
978-1-59259-976-9 (ISBN)

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A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

Part I. Fundamental Issues Related to Natural Product-Based Drug Delivery

Natural Products and Drug Discovery
Arnold L. Demain and Lixin Zhang

Part II. Strategies

Integrated Approaches for Discovering Novel Drugs From Microbial Natural Products
Lixin Zhang

Automated Analyses of HPLC Profiles of Microbial Extracts: A New Tool for Drug Discovery Screening
José R. Tormo and Juan B. García

Manipulating Microbial Metabolites for Drug Discovery and Production
C. Richard Hutchinson

Improving Drug Discovery From Microorganisms
Chris M. Farnet and Emmanuel Zazopoulos

Developments in Strain Improvement Technology: Evolutionary Engineering of Industrial Microorganisms Through Gene, Pathway, and Genome Shuffling
Stephen B. del Cardayré

Part III. Specific Groups of Drugs

The Discovery of Anticancer Drugs From Natural Sources
David J. Newman and Gordon M. Cragg

Case Studies in Natural-Product Optimization: Novel Antitumor Agents Derived From Taxus brevifolia and Catharanthus roseus
Jian Hong and Shu-Hui Chen

Terpenoids As Therapeutic Drugs and Pharmaceutical Agents
Guangyi Wang, Weiping Tang, and Robert R. Bidigare

Challenges and Opportunities in the Chinese Herbal Drug Industry
Wei Jia and Lixin Zhang

Arsenic Trioxide and Leukemia: From Bedside to Bench
Guo-Qiang Chen, Qiong Wang, Hua Yan, and Zhu Chen

Part IV. Microbial Diversity

New Methods to Access Microbial Diversity for Small Molecule Discovery
Karsten Zengler, Ashish Paradkar, and Martin Keller

Accessing the Genomes of Uncultivated Microbes for Novel Natural Products
Asuncion Martinez, Joern Hopke, Ian A. MacNeil, and Marcia S. Osburne

Part V. Specific Sources

New Natural-Product Diversity From Marine Actinomycetes
Paul R. Jensen and WilliamFenical

Novel Natural Products From Rainforest Endophytes
Gary Strobel, Bryn Daisy, and Uvidelio Castillo

Biological, Economic, Ecological, and Legal Aspects of Harvesting Traditional Medicine in Ecuador
Alexandra Guevara-Aguirre and Ximena Chiriboga

Index

Erscheint lt. Verlag 17.11.2007
Zusatzinfo XIV, 386 p. 184 illus.
Verlagsort Totowa
Sprache englisch
Themenwelt Medizin / Pharmazie Gesundheitsfachberufe
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Naturheilkunde
Medizin / Pharmazie Pflege
Medizin / Pharmazie Pharmazie PTA / PKA
Schlagworte Cancer • Drug • Drug Delivery • drug discovery • Research
ISBN-10 1-59259-976-1 / 1592599761
ISBN-13 978-1-59259-976-9 / 9781592599769
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