Viral Proteases and Antiviral Protease Inhibitor Therapy (eBook)
XI, 132 Seiten
Springer Netherland (Verlag)
978-90-481-2348-3 (ISBN)
The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles' heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.
The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles' heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.
Preface 6
Contents 8
Contributors 9
Chapter 1 Study of Inhibitors Against SARS Coronavirus by Computational Approaches 12
1.1 Introduction 13
1.2 Binding Interactions 14
1.3 Narrow down the Compounds-Searching Scope by Pharmacophore Approach 15
1.3 Narrow down the Compounds-Searching Scope by Pharmacophore Approach 15
1.4 Winnow for Anti-SARS Drug Candidates by Molecular Docking Operation 19
1.5 Distorted-Key Theory and Peptide Inhibitors 20
1.6 Using Graphic Approaches to Detect SARS-Coronavirus 24
1.7 Identification of Proteases and Their Types 24
1.8 Conclusion 30
References 31
Chapter 2 HIV-1 Protease and AIDS Therapy 35
2.1 Introduction 36
2.2 Role of HIV-1 Protease in Viral Replication 36
2.3 Structure and Specificity of HIV-1 Protease 38
2.4 The Challenge of Drug Resistance 42
2.5 Comparative Analysis of Retroviral Proteases 44
2.6 Structure-Guided Drug Design: Current and Future Prospects 45
2.7 Conclusion 50
References 50
Chapter 3 Hepatitis C Virus 56
3.1 Introduction 56
3.2 Host Cell Proteases 59
3.3 NS3 Protein 60
3.4 NS2/3 Autoprotease 64
3.5 Conclusions 71
References 72
Chapter 4 Antiviral Activity of Proteasome Inhibitors/Cytomegalovirus 79
4.1 Introduction 79
4.2 Proteasome and Inhibitors 80
4.3 Influence of Proteasome Inhibitors on HCMV Replication 82
4.4 Conclusions 87
References 88
Chapter 5 Rational Drug Design of HTLV-I Protease Inhibitors 90
5.1 Introduction 90
5.2 The HTLV-I Protease 92
5.3 HIV Protease Inhibitors 94
5.4 The Central Inhibitory Unit 96
5.5 A Truncation Study on HTLV-I Protease Inhibitors 98
5.6 Amino Acid Substitution Studies on HTLV-I Protease Inhibitors 99
5.7 P1 - and P3-Capping Groups in HTLV-I Protease Inhibitors 100
5.8 Computer-Assisted Docking Simulations of HTLV-I Protease and Its Inhibitors 101
5.9 Conclusion: Outline of HTLV-I Protease Inhibitor Development 103
References 104
Chapter 6 Picornaviruses 108
6.1 Introduction 108
6.2 Picornaviral 3C Proteinases 114
6.3 Enteroviral and Rhinoviral 2A Proteinases 119
6.4 Aphthoviral L Protease 127
6.5 Conclusions 130
References 131
Index 138
| Erscheint lt. Verlag | 19.6.2009 |
|---|---|
| Reihe/Serie | Proteases in Biology and Disease | Proteases in Biology and Disease |
| Zusatzinfo | XI, 132 p. |
| Verlagsort | Dordrecht |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Allgemeines / Lexika |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin | |
| Studium ► Querschnittsbereiche ► Infektiologie / Immunologie | |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie | |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| Technik | |
| Schlagworte | AIDS • Antiviral Drug • Biology • Infection • Infections • Infectious Diseases • Viral Infection • Virus |
| ISBN-10 | 90-481-2348-8 / 9048123488 |
| ISBN-13 | 978-90-481-2348-3 / 9789048123483 |
| Haben Sie eine Frage zum Produkt? |
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