Radiation Toxicity: A Practical Medical Guide (eBook)

Contents 7
List of Contributors 9
Introduction 12
1. The Management of Radiation-Induced Brain Injury 15
2. MANAGEMENT OF RADIATION-INDUCED HEAD AND NECK INJURY 31
1. The Management of Radiation-Induced Brain Injury 15
INTRODUCTION 15
A. PATHOGENESIS OF RADIATION-INDUCED CNS INJURY 15
B. CLINICAL ASPECTS OF CNS RADIATION TOLERANCE 20
C. QUANTITATIVE SCORING OF CNS TOXICITY 22
D. MANAGEMENT OF RADIATION-INDUCED CNS INJURY 24
2. Management of Radiation-Induced Head and Neck Injury 31
INTRODUCTION 31
A. ETIOLOGY AND PATHOGENESIS 33
B. PATIENT EDUCATION AND DENTAL EVALUATION PRECEDING IRRADIATION 34
C. PRACTICAL ASPECTS OF ACUTE AND LATE EFFECT MANAGEMENT FOLLOWING CANCER THERAPY 34
D. STUDIES ADDRESSING SPECIFIC ISSUES REGARDING TREATMENT-RELATED TOXICITIES IN IRRADIATED H& N CANCER PATIENTS
E. MEDICAL MANAGEMENT OF XEROSTOMIA AND MUCOSITIS 39
F. SUMMARY 46
REFERENCES 46
3. Radiation Pneumonitis and Esophagitis in Thoracic Irradiation 50
INTRODUCTION 50
A. COMPLICATIONS OF IRRADIATION TO THE THORAX 51
B. LUNG TOXICITY 52
C. FUTURE DIRECTIONS RELATED TO LUNG TOXICITY 59
D. ESOPHAGEAL TOXICITY 60
E. CONCLUSION 68
REFERENCES 68
4. Toxicity from Radiation in Breast Cancer 72
A. ACUTE REACTIONS 73
B. LATE TOXICITY 85
REFERENCES 109
5. Upper Gastrointestinal Tract 117
A. BIOLOGY OF RADIATION EFFECTS 117
B. CLINICAL ISSUES 119
REFERENCES 127
6. Radiation Complications of the Pelvis 131
INTRODUCTION 131
A. COMPLICATIONS RELATED TO GI EFFECTS 131
B. GU EFFECTS 138
REFERENCES 155
7. Radiation-Induced Skeletal Injury 160
INTRODUCTION 160
A. MANDIBULAR OSTEORADIONECROSIS 160
B. LONG BONE FRACTURE 164
C. FEMORAL HEAD AND NECK 165
D. PELVIS 167
E. RIB FRACTURES 169
F. PEDIATRIC GROWTH ABNORMALITIES 170
G. OTHER PEDIATRIC SKELETAL TOXICITIES 172
G1. Management 172
REFERENCES 172
8. Skin Changes 175
A. NORMAL SKIN RESPONSE TO RADIATION 175
B. ACUTE SKIN EFFECTS 176
C. SUMMARY 184
REFERENCES 184
Index 186