Antiangiogenic Agents in Cancer Therapy (eBook)

Preface 6
Contents 7
Contributors 10
I Basic Biology of Angiogenesis 18
Vascular Endothelial Growth Factor Family and Its Receptors 19
The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors 43
The Role of Integrins in Tumor Angiogenesis 64
Tumor Endothelial Cell Abnormalities 87
The Extracellular Matrix and VEGF Processing 99
Endothelial Precursor Cells 112
Role of Pericytes in Angiogenesis 129
Newer Vascular Targets 145
Chemokines in Angiogenesis 166
Angiopoietin/Tie2 Signaling Regulates Tumor Angiogenesis 182
Imaging Angiogenesis 199
Tumor Blood Vessels 214
Lymphatic System in the Pathology of Cancer 234
II Translational Research in Tumor Angiogenesis 251
VEGF in the Adult 252
Normalization of Tumor Vasculature and Microenvironment 267
Metronomic Low-Dose Antiangiogenic Chemotherapy in Mice and Man 283
Small-Molecule Vascular Disrupting Agents in Cancer Therapy 303
Normalization of Tumor Vasculature and Improvement of Radiation Response by Antiangiogenic Agents 317
Challenges in Translating Antiangiogenic Therapy from the Bench to Bedside 328
Regulation of Angiogenesis in Cancer and Its Therapeutic Implications 336
III Antiangiogenic Therapy in the Clinical Trial Results and Future Directions 355
Angiogenesis and Angiogenesis Inhibition in Sarcomas 356
Antiangiogenesis Agents in Colorectal Cancer 373
Antiangiogenic Therapy for Primary CNS Tumors 413
Angiogenesis Inhibitors for the Treatment of Lung Cancer 437
Antiangiogenic Therapy of Renal Cell Carcinoma 455
Antiangiogenesis Therapies in Gynecologic Malignancies 468
Antiangiogenic Agents in Myeloid Malignancies 484
Angiogenesis in Malignant and Non- Malignant Pediatric Tumors 501
Prognostic and Predictive Significance of Surrogate Biomarkers of Angiogenesis 513
Endpoints for the Determination of Efficacy of Antiangiogenic Agents in Clinical Trials 535
The Role of Imaging in the Clinical Development of Antiangiogenic Agents 551
Index 563