Multimodal Concepts for Integration of Cytotoxic Drugs (eBook)

J. Martin Brown, PhD, is a Professor of Radiation Oncology at Stanford University. He was president of the Radiation Research Society and member of several program and award committees of the American Association for Cancer Research. Dr. Brown is currently the senior editor for biology for the International Journal of Radiation Oncology Biology Physics. He has received a number of awards, including an NIH M.E.R.I.T. Award, the Research Award from the Radiation Research Society, the 1999 Cain Memorial Award from the American Association for Cancer Research, the 1999 ASTRO Gold Medal, and the Weiss Medal from the Association for Radiation Research. Minesh P. Mehta, MD, is Professor and Chairman of the Department of Human Oncology, University of Wisconsin Medical School, Madison. He is the Chairman of the Radiation Therapy Oncology Group Brain Tumor Committee and is on the editorial board of the Journal of Neuro-Oncology and the International Journal of Cancer Research. Carsten Nieder, MD, is head of the Radiation Oncology Section of the Multidisciplinary Cancer Center and deputy head of the Stereotactic Central Nervous System Radiotherapy program, Klinikum rechts der Isar, Munich. He has received a 2-year research scholarship from the Mildred Scheel Foundation and the Hanns Langendorff Award 2003. Dr. Nieder is on the editorial board of Reviews of Recent Randomized Trials.

Foreword 5
Preface 6
Contents 8
I. Preclinical Part 10
1 Biological Basis of Combined Radio- and Chemotherapy 11
2 Combinations of Antimetabolites and Ionizing Radiation 26
3 Combinations of Taxanes and Ionizing Radiation 42
4 Combinations of Topoisomerase Inhibitors and Ionizing Radiation 59
5 Combinations of Hypoxia- Targeting Compounds and Radiation- Activated Prodrugs with Ionizing Radiation 73
6 Combinations of Platinum Compounds and Ionizing Radiation 98
7 Combinations of Cytotoxic Drugs, Ionizing Radiation, and Angiogenesis Inhibitors 107
8 Combinations of Cytotoxic Drugs, Ionizing Radiation and EGFR Inhibitors 119
9 Combinations of Cytotoxic Drugs, Ionizing Radiation, and Mammalian Target of Rapamycin ( mTOR) Inhibitors 130
10 Combinations of Ionizing Radiation and Other Sensitizing Agents 141
11 Radiotherapy and Tumor- Targeted Drug Delivery 152
II. Clinical Part 164
12 Applications in Malignant Brain Tumors 165
13 Applications in Head and Neck Cancer 187
14 Applications in Esophageal and Gastric Cancer 197
15 Novel Chemoradiation in Localized Pancreatic Cancer: Clinical Studies 214
16 Applications in Lung Cancer 229
17 Integration of Radiation Therapy and Systemic Therapy for Breast Cancer 249
18 Applications in Rectal and Anal Cancer 264
19 Concomitant Radiation and Chemotherapy in Muscle- Invasive Bladder Cancer 281
20 Applications to Gynecological Cancers 299
21 Early and Late Treatment- Induced Toxicity 312
22 Feasibility of Combined Chemo- and Radiation Treatment in Elderly/ Comorbid Patients 328
Subject Index 336
List of Contributors 339