Focal Therapy in Prostate Cancer

Edited by Hashim U. Ahmed, Division of Surgery and Interventional Science, University College London, London, UK Manit Arya, Department of Urology, University College London, London, UK Peter R. Carroll, Department of Urology, University of California, San Francisco, CA, USA Mark Emberton, Division of Surgery and Interventional Science, University College London, London, UK

Contributor List, vii Preface, xi Section I Is there a role for Focal Therapy in Localised Prostate Cancer?, 1 1 The Rationale for Focal Therapy of Prostate Cancer, 3 Cole Davis, Matthew Cooperberg, and Peter R. Carroll 2 Factors That Affect Patients' Choice of Treatment, 11 Deb Feldman-Stewart and Michael D. Brundage 3 Histological Trends and the Index Lesion in Localized Prostate Cancer, 17 Vladimir Mouraviev, Thomas Wheeler, and Thomas J. Polascik 4 Selection Criteria for Prostate Cancer Focal Therapy, 29 Rajat K. Jain, Timothy K. Ito, and Samir S. Taneja Section II How can we accurately locate cancer within the gland?, 37 5 Localisation of Cancer within the Gland: Biopsy Strategies, 39 Winston E Barzell and Rodrigo Pinochet 6 Localisation of Cancer within the Gland: Ultrasound Imaging, 47 Ulrich Scheipers 7 Localization of Cancer within the Prostate: Dynamic Contrast-Enhanced MRI, 55 Philippe Puech, Anwar Padhani, Laurent Lemaitre, Nacim Betrouni, Pierre Colin, and Arnauld Villers 8 Localization of Cancer within the Gland: Diffusion-Weighted Magnetic Resonance Imaging of the Prostate, 66 Sophie F Riches, Nina Tunariu, and Nandita M deSouza 9 The future of Molecular and Biomolecular Imaging in Prostate Cancer, 75 Michael S. Gee and Mukesh G. Harisinghani Section III How can we create discrete tissue necrosis?, 85 10 Energies for Focal Ablation: Cryoablation, 87 John F. Ward 11 Focal Salvage Cryoablation in Recurrent Prostate Cancer, 98 Katsuto Shinohara 12 High-Intensity Focused Ultrasound, 106 Hashim Uddin Ahmed and Mark Emberton 13 Energies for Focal Ablation: Photodynamic Therapy, 114 Caroline M. Moore, Nimalan Arumainayagam and Mark Emberton 14 Focal Therapy for Prostate Cancer Using Radiation, 126 Irving Kaplan, Elizabeth Genega and Neil Rofsky 15 Image Registration and Fusion for Image-Guided Focal Ablation, 132 Dean Barratt and David Hawkes Section IV How can we determine the success of Focal Therapy? , 143 16 Determining Success of Focal Therapy: Biochemical and Biopsy Strategies, 145 Al Barqawi, Paul Maroni, and David Crawford 17 Determining Success of Focal Therapy: Imaging, 153 Alex Kirkham and Clare Allen 18 Evaluating Focal Therapy: Future Perspectives, 170 Hashim Uddin Ahmed and Mark Emberton Index, 179 Colour plate section can be found facing page 116