Obesity

Debasis Bagchi is a professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy in Texas and the Director of Innovation & Clinical Affairs at Iovate Health Sciences Research Inc., in Oakville, Canada. His research interests include free radicals, human diseases, carcinogenesis, pathophysiology, mechanistic aspects of cytoprotection by antioxidants, and regulatory pathways in obesity, diabetes, and gene expression. He has received funding from various institutions and agencies, including the U.S. Air Force Office of Scientific Research, Nebraska State Department of Health, Biomedical Research Support Grant from National Institutes of Health (NIH), National Cancer Institute (NCI), Health Future Foundation, The Procter & Gamble Company, and Abbott Laboratories. Dr. Bagchi received the Master of the American College of Nutrition Award in 2009. He has authored 287 peer- reviewed publications and 15 books. Harry G. Preuss is a tenured professor at Georgetown University (Washington, D.C.) in four departments—biochemistry, physiology, medicine, and pathology. His current research, both laboratory and clinical, centers on the use of dietary supplements and nutraceuticals to favorably influence or even prevent a variety of medical perturbations, especially those related to obesity, insulin resistance, and cardiovascular disorders. He has also researched the ability of essential oils and fats to overcome various infections, including those resistant to antibiotics. He recently won the coveted Charles E. Ragus Award of the American College of Nutrition (ACN) for publishing the best research paper in their journal for the year 2006 and the ACN Award for 2010 given to an outstanding senior investigator in nutrition.

Introduction. Epidemiology of Obesity. Epidemiology of Type 2 Diabetes and Obesity. Pathophysiology of Obesity. Global View on the Development of Noncommunicable Diseases. Evidence for Refined Food Addiction. Disruption of Development by Environmental Estrogens. Cigarette Smoking, Inflammation, and Obesity. Role of Neurotransmitters in Obesity Regulation. Neurobiology of Obesity. Leptin as a Vasoactive Adipokine. Leptin-Induced Inflammation. Overview of Ghrelin, Appetite, and Energy Balance. Molecular Genetics of Obesity Syndrome. Sleep and Obesity. Obesity and Degenerative Diseases. Oxidative Stress Status in Humans with Metabolic Syndrome. Obesity and Type 2 Diabetes. Inflammation. Angiogenesis-Targeted Redox-Based Therapeutics. Obese and Overweight. Genomic Imprinting Disorders in Obesity. Novel Concept in Obesity Drug Development. Adipose Drug Targets for Obesity Treatment. History and Regulation of Prescription and Over-the-Counter Weight Loss Drugs. Safety of Obesity Drugs. Safety of Obesity Drugs. Historical Perspective, Efficacy of Current Drugs, and Future Directions in the Management of Obesity. Natural, Nutritional, and Physical Approaches of Weight Management. Essential Role of Exercise and Physical Activity in Weight Management. Role of Exercise in Diet and Weight Loss. Role of Exercise in Weight Management and Other Health Benefits. Overview of Nutritional and Dietary Approaches for Weight Control. Gender Effects on Adiposity. Beyond Obesity Prevention. Carbohydrate Digestion Inhibitors. Vegetarian Diets in the Prevention and Treatment of Obesity. Atkins Paradigm. Nature vs. Nurture. Glycemic Index. Chromium (III) in Promoting Weight Loss and Lean Body Mass. An Overview on (−)-Hydroxycitric Acid in Weight Management. Review of the Safety and Efficacy of Bitter Orange () and Its Primary Protoalkaloid, -Synephrine, in Weight Management. Antiobesity Effects of Conjugated Linoleic Acid. Role of Tea in Weight Management. Laboratory and Clinical Studies of Chitosan. Role of Curcumin, the Golden Spice, in Obesity and Associated Chronic Diseases. Role of in Weight Management. Glucomannan in Weight Loss. Role of Medium-Chain Triglycerides in Weight Management. Antiobesity by Marine Lipids. Dairy Foods, Calcium, and Weight Management. Lessons from the Use of Ephedra Products as a Dietary Supplement. Extract in the Management of Obesity. Curcumin. Review of the Safety and Efficacy of Banaba (L.) and Its Major Constituents, Corosolic Acid and Ellagitannins, in the Management of Metabolic Syndrome. Appetite, Body Weight, Health Implications of a Low-Glycemic-Load Diet. Herbals and Dietary Nutrients Associated with Weight Loss. Calcium and Obesity. Dietary Supplementation in Weight Loss. Beyond Glycemic Index and Glycemic Load. Challenges to the Conduct and Interpretation of Weight Loss Research. Child Obesity and Prevention. Obesity and Disordered Eating in Youth. Childhood Obesity. Impact of Childhood Obesity on Musculoskeletal Growth, Development, and Disease. New Directions in Childhood Obesity. Thinking Outside the Box. Bariatric Surgery in Weight Management. Bariatric Surgery and Reversal of Metabolic Disorders. Bariatric Surgery in Pediatric Weight Management. Index.