Botulinum Toxins

Joel L. Cohen MD, Director, AboutSkin Dermatology and DermSurgery (Greenwood Village and Lone Tree, Colorado); Associate Clinical Professor, University of Colorado Department of Dermatology, CO, USA, and; Assistant Clinical Professor, University of California Irvine Department of Dermatology, CA, USA

David M. Ozog MD, Chair, Department of Dermatology, C.S. Livingood Chair of Dermatology, and Director of Cosmetic Dermatology, Henry Ford Hospital; Assistant Professor, Wayne State University, Detroit, MI, USA

Dennis A. Porto MD, (Video Editor), Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA

List of Contributors vii


Treatment of the Periocular Area Crow s Feet, Brow, and Bunny Lines 165
Girish S. Munavalli, MD (MHS, FACMS), Anthony V. Benedetto, DO (FACP, FCPP), Brian S. Biesman, MD (FACS), and Carolee M. Cutler Peck, MD


About the Companion Website xiii


Video Table of Contents xv


1 History of Botulinum Toxin for Medical and Aesthetic Use 1
Alastair Carruthers, FRCPC and Jean Carruthers, MD (FRCS(C), FRCOphth)


2 Anatomy and Aesthetic Principles 13
Timothy M. Greco, MD (FACS), Che'rie M. Ditre, MD, and David M. Ozog, MD (FAAD, FACMS)


3 Botulinum Toxin: From Molecule to Medicine 37
Conor J. Gallagher, PhD and Alan Ackerman, PhD


4 Myobloc 53
Neil S. Sadick, MD (FACP, FAAD, FAACS, FACPh) and Suveena Manhas-Bhutani, MD


5 Abobotulinumtoxin: Development and Aesthetic Usage 65
Gary D. Monheit, MD


6 IncobotulinumtoxinA (Xeomin (R)/Bocouture (R)) 79
Ulrich Kuhne, MD (DALM) and Matthias Imhof, MD (DALM)


7 Future Injectable Toxins 97
Michael H. Gold, MD


8 Reconstitution, Dilution, Di usion, and Migration of Botulinum Toxin 109
Murad Alam, MD (MSCI, MBA), Hayes B. Gladstone, MD, and David M. Ozog, MD (FAAD, FACMS)


9 Patient Selection 121
Ryan M. Greene, MD (PhD, FACS), John P. Arkins, BS, and Steven H. Dayan, MD (FACS)


10 Treatment of the Glabella 133
Neal D. Varughese, MD (MBA) and David J. Goldberg, MD (JD)


11 Treatment of the Forehead 147
Joel L. Cohen, MD (FAAD, FACMS) and Ramin Fathi, MD


12 Treatment of the Periocular Area - Crow's Feet, Brow and Bunny Lines
Girish S. Munavalli, MD(MHS, FACMS), Antony V. BEnedetto, DO (FACP, FCPP), Brian S. Biesman, MD (FACS), and Carolee M. Cutler Peck, MD

13 Contouring of the Lower Face and of the Lower Leg and Calf 177
Mee young Park, MD (PhD), Dennis A. Porto, MD, and Ki Young Ahn, MD (PhD)


14 Treatment of the Perioral Area 191
Shawn Allen, MD (FAAD, FACMS), Roberta Sengelmann, MD, and Rachel Simmons, MD (FAAD)


15 Neck Rejuvenation 199
Koenraad De Boulle, MD, Lakhdar Belhaouari, MD, and Julia D. Kreger, MD


16 Correction of Facial Asymmetry 213
Scott Rickert, MD (FACS), Lesley F. Childs, MD, and Andrew Blitzer, MD (DDS, FACS)


17 Complications and Di usion 221
Matteo C. LoPiccolo, MD, Farhaad R. Riyaz, MD, and David M. Ozog, MD (FAAD, FACMS)


18 Combination Therapy of Botulinum Toxin with other Nonsurgical Procedures 233
Amy Forman Taub, MD and Lauren Fine, MD (FAAD)


19 Peri-Procedure Botulinum Toxin for Skin Cancer Patients and Scars 253
Timothy Corcoran Flynn, MD, Molly C. Powers, MD, and David M. Ozog, MD (FAAD, FACMS)


20 Achieving a Natural Look 263
Doris Hexsel, MD, Camile L. Hexsel, MD (FAAD, FACMS), and Carolina Siega, BSc


21 Special Considerations in Darker Skin 275
Chere' Lucas Anthony, MD and Marta I. Rendon, MD (FAAD, FACP)


22 Axillary Hyperhidrosis 285
Ada Regina Trindade de Almeida, MD, Joel L. Cohen, MD (FAAD, FACMS), and Chinobu Chisaki, MD


23 Primary Focal Palm, Sole, Craniofacial, and Compensatory Hyperhidrosis 299
Dee Anna Glaser, MD and Adam R. Mattox, DO (MS)


24 Topical Botulinum Toxin 317
Richard G. Glogau, MD and Eileen Axibal, MD


25 Exciting New Uses of Botulinum Toxin Type A: Dermatology/Dermatologic Surgery and Beyond 329
Donna Bilu Martin, MD (FAAD) and Stephen Mandy, MD (FAAD)


26 Modulating A ect and Mood with Botulinum Toxin Injections: Psychosocial Implications of Neuromodulators 345
James L. Griffith, MD (MSci), Kevin C. Smith, MD (FRCPC (DERM)), and Murad Alam, MD (MSCI, MBA)


27 OnabotulinumtoxinA (Botox (R)) in Dermatology 357
Jason J. Emer, MD, Eileen Axibal, MD, Ellen S. Marmur, MD (FAAD), and Heidi Waldorf, MD


Index 369