Barrett’s Esophagus

Norman Barrett and the esophagus.- Section 1: Normal Anatomy and Physiology of the Esophagus.- 1.1 Anatomy and embryology of the esophagus.- 1.2 Cell biology of the esophageal epithelium.- 1.3 Normal physiology of the esophagus.- 1.4 Pathophysiology of gastro-esophageal reflux disease.- Section 2: Gastro-Esophageal Reflux Disease.- 2.1 The natural history of gastro-esophageal reflux disease.- 2.2 Helicobacter pylori and reflux disease.- 2.3 Acid and bile in the esophagus.- 2.4 Endoscopie classification of gastro-esophageal reflux disease.- 2.5 Optimal surgical therapy for anti reflux disease.- 2.6 Surgical treatment of duodeno-gastro esophageal reflux.- Section 3: Barrett’s Esophagus — Diagnosis.- 3.1 Histopathology of Barrett’s esophagus.- 3.2 The metaplasia-dysplasia-carcinoma sequence of Barrett’s esophagus.- 3.3 Genetic alterations.- 3.4 Endoscopic surveillance.- 3.5 Short segment Barrett’s esophagus and intestinal metaplasia at the gastro-esophageal junction.- Section 4: Barrett’s Esophagus — Treatment.- 4.1 Prevention of cancer by control of reflux.- 4.2 Prevention of cancer in Barrett’s by ablation.- 4.3 The role of ablation in the management of high-grade dysplasia.- 4.4 Surgical treatment of high-grade dysplasia and superficial carcinoma.- Section 5: Adenocarcinoma in Barrett’s.- 5.1 Epidemiology of Barrett’s esophagus and adenocarcinoma.- 5.2 Adenocarcinoma in Barrett’s esophagus: signs, symptoms and endoscopic appearance.- 5.3 Adenocarcinoma in Barrett’s esophagus: classification and staging.- 5.4 Diagnosis and implications of bone marrow micrometastases.- Section 6: Treatment of Adenocarcinoma.- 6.1 Indications and outcome of esophageal resection.- 6.2 Transhiatal esophagectomy.- 6.3 Resection of esophageal carcinoma: the role of lymfnode dissection.- 6.4 Videoendoscopic esophagectomy for cancer.- 6.5 Management of postoperative complications.- 6.6 Multimodality in the management of adenocarcinoma of the esophagus.- 6.7 Endoscopie management of dysphagia from esophageal cancer.- Section 7: Quality of Life.- 7.1 Function and quality of life after esophageal resection.