Small-Molecule Inhibitors of Protein-Protein Interactions

Lyubomir Vassilev, David Fry (Herausgeber)

Buch | Hardcover
X, 174 Seiten
2011 | 2011
Springer Berlin (Verlag)
978-3-642-17082-9 (ISBN)
160,49 inkl. MwSt
In this volume, the editors have collected the knowledgeable insights of researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions.

In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. These researchers describe their unique approaches, and share experiences, results, thoughts, and opinions. The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies. There are various focal points, including methodologies and the molecules themselves. Ultimately, there are numerous lessons to be taken away from this collection, and the editors hope that this snapshot of the current state of the art in developing protein-protein inhibitors not only pays tribute to the past successes, but also generates excitement about the future potential of this field

Preface.- Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions.- Small-molecule inhibitors of IL-2/IL-2R: lessons learned and applied.- Small Molecule Inhibitors of the Human Papillomavirus E1-E2 Interaction.- Design of small-molecule Smac mimetics as IAP antagonists.- Small-molecule inhibitors reveal a new function for Bcl-2 as a pro-angiogenic signaling molecule.- Small-molecule modulators of c-Myc/Max and Max/Max interactions.- Small-molecule inhibitors of the p53-MDM2 interaction.- Subject index

Erscheint lt. Verlag 12.1.2011
Reihe/Serie Current Topics in Microbiology and Immunology
Zusatzinfo X, 174 p.
Verlagsort Berlin
Sprache englisch
Maße 155 x 235 mm
Gewicht 478 g
Themenwelt Medizin / Pharmazie Studium
Schlagworte alpha-helix mimicry • Apoptosis • beta-strand/beta-sheet mimicry • c-MYC • HPV11 • HPV16 • HPV18 • HPV6 • IL-2/IL-2R • MDM2 • p53 • pro-angiogenic signaling molecule • XIAP
ISBN-10 3-642-17082-X / 364217082X
ISBN-13 978-3-642-17082-9 / 9783642170829
Zustand Neuware
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